Lecture 6: Cytoskeleton III (Microtubule)

Question 1

What are microtubule heterodimer composed of ?

Answer 1

alpha and beta tubulin

Question 2

What is hydrolyzed on b-tubulin during MT formation?

Answer 2

GTP

Question 3

High concentration of a/b tubulin heterodimer means

Answer 3

GTP cap forms and MT grow

Question 4

Lack of GTP cap at low a/b tubulin heterodimer concentration means

Answer 4

MT will depolymerize

Question 5

dynamic instability of MT depend on

Answer 5

-cytosolic concentration of GTP bound a/b tubulin heterodimer
-presence/absence of GTP cap

Question 6

Which ends are capped and protected from depolymerization?

Answer 6

(-) ends

Question 7

Treadmilling is less important for MTS because …

Answer 7

of the (-) end capping mechanism

Question 8

Kinesin moves cargo towards

Answer 8

(+) end

Question 9

Dynein moves cargo towards

Answer 9

(-) end

Question 10

Binding with _ and _ is required for MT motor protein function

Answer 10

ATP, MT