Lecture 12: Protein and transport IV Flashcards
1
Q
anterograde
A
- first step of secretory pathway
- mediated by COPII vesicles
2
Q
retrograde
A
- mediated by COPI vesicles
- retrieve functions
- v-snare
-membranes
-mis-sorted ER proteins
3
Q
what is a lysosome
A
various digestive functions
-breakdown of intra/extracellular materials
-destruction of phagocytosed micro-organisms
-provide nutrient products for cells
4
Q
at what ph do lysosomes work best
A
low ph
5
Q
lysosome sorting signal and clathrin vesicle formation
A
starts from the golgi
6
Q
sorting signal
A
M6P
7
Q
receptor
A
M6P receptor
8
Q
vesicle coat
A
clathrin complex
9
Q
early stage involves
A
COPII and COPI vesicles
10
Q
late stage involves
A
clathrin coated vesicles
11
Q
plasma membrane to endosome to lysosome
A
endocytosis
12
Q
Familial Hypercholesterolemia
A
increase LDL level in serum by affecting the receptor mediated by LDL endocytosis
