Lecture 6- blood gas transport

Question 1

Does an increase in temp move dissociation curve to right or left

Answer 1

right

Question 2

Does an increase in pH move dissociation curve to right or left

Answer 2

left- so increased PCO2 moves curve right as it lowers the pH

Question 3

Does an increase in 2,3-DPG move dissociation curve to right or left

Answer 3

right

Question 4

What happens when Hb is in the tense state

Answer 4

affinity for O2 is decreased and O2 is forced out of Hb

Question 5

what happens when Hb is in the relaxed state

Answer 5

affinity for O2 is high so O2 can easily reach haem group

Question 6

define a buffer

Answer 6

a solution that can minimise changes in the free H+ concentration and therefore in pH- usually a weak acid and its base

Question 7

What is the most common buffer system in the body

Answer 7

bicarbonate (carbonic acid)

Question 8

What are the three ways CO2 is carried in the blood

Answer 8

dissolved, carbamino compounds (bound to R-NH2), as carbonic acid/bicarbonate

Question 9

What compensation systems are there for controlling the acid base balance

Answer 9

respiratory- blood pH regulates ventilation so controls pCO2

renal- excretion of H+ controlled by pH

Question 10

what is respiratory alkalosis

Answer 10

low pCO2, normal HCO3-

Question 11

what is metabolic alkalosis

Answer 11

normal PCO2, high HCO3-

Question 12

what is respiratory acidosis

Answer 12

high PCO2, high HCO3-

Question 13

what is metabolic acidosis

Answer 13

low PCO2, low HCO3-