Lecture 6 - Bioenergetics 1 Flashcards

1
Q

what are substrates and list the diferent types

A

fuel sources from which we make energy (ATP)

  • > these are comprised of three groups
    1. carbohydrates
    2. Fats
    3. proteins
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2
Q

bioenergetics

A

the conversion of substrates into energy

  • > this process occurs at the cellular level
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3
Q

metabolism

A

the chemical processes that happen in the body to convert food to energy

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4
Q

1 calorie (cal)

A

is the heat energy required to raise 1g of water from 14.5 to 15.5

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5
Q

cal vs kcal vs Calorie

A

1000 cal = 1 kcal = 1 Calorie

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6
Q

substrates are made up of which 4 elements

A
  • > carbon
  • > hydrogen
  • > oxygen
  • > nitrogen (only in proteins)
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7
Q

where is energy from chemical bonds in food stored?

A

in a high energy compound called ATP

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8
Q

when are substrates consumed

A

Resting

  • > 50% carbs 50% fats

Exercise (short term)

  • > more carbs

Exercise (long)

  • > carbs and fats, proteins only consumed for energy in dire situations
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9
Q

characteristics of carbs

A

all carbs are converted to glucose

  • > 4.1 kcal/g (2500 kcal stored in body)
  • > extra glucose is stored as glycogen in the liver and muscles
  • > glycogen converted to glucose when needed to make ATP
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10
Q

characteristics of fat

A
  • > very efficient substrate with efficient storage capabilities
  • > 9.4 kcal/g (70000+ kcal stored in bogy)
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11
Q

where are carbs and fats stored

A

*know general trends*

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12
Q

characteristics of protein

A
  • > used as substrate only during starvation (converted into glucose)
  • > 4.1 kcal/g
  • > converted into Free Fatty Acids through lipogenesis which is used for energy storage and cellular energy
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13
Q

how are fats, carbs and proteins used for energy production

A
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14
Q

what controls the rate of energy production

A

substrate availability

  • > more available substrate yields higher pathway activity; this is known as the Mass Action Effect

enzyme activity

  • > enzymes act as chemical catalysts in specific steps of metabolism (they do not start chemical reactions, they lower the activation energy of a reaction, see picture)
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15
Q

how do enzymes change the activation energy

A
  • > specific enzymes are required for each step of the biochemical pathway
  • > more enzyme activity = more product
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16
Q

rate limiting enzymes

A
  • > slows the overall reaction, prevents runaway reaction
  • > limits available enzymes required to start one of the early steps in the biochemical pathway
17
Q

ATP breakdown formula

A

ATP + water +ATPase = ADP + Pi + energy

  • > can occur with or without oxigen
  • > reversed by phosphorylation
18
Q

how much ATP does your body store and why

A

its stored in small amounts (until needed)

  • > it’s stored in small amounts because it is a very large and bulky molecule, inefficient to store it all at one
19
Q

characteristics of ATP-PCr systems

A
  • > anaerobic, substrate level metabolism
  • > ATP yield: 1 mol ATP/1 mol Phosphocreatine
  • > lasts 3-15sec

PCr + creatine kinASE - > Creatine + Pi + energy

20
Q

how is the ATP-PCr system regulated/controlled?

A

phosphcreatine breakdown is catalyzed by an enzyme called creatine kinase (CK)

  • > CK controls the rate of ATP production via a negative feedback systme (when ATP drops, CK levels goes up to fix it, and vice versa)
21
Q

characteristics of the glycolytic/lactic acid system

A
  • > anaerobic
  • > yields 2-3 mol ATP / 1 mol substrate

*2ATP for glucose, 3 for glycogen

  • > lasts 15s - 2mins

- > breakdown of glucose/glycogen via glycolysis

  • > 10-12 enzymatic reaction (glucose-6-pi and ends with pyruvate)
22
Q

characteristics of the oxidative system

A
  • > aerobic
  • > ATP yield is dependant on substrate
  • 32-33 ATP/ 1 glucose
  • 100+ ATP / 1 FFA
  • > duration: steady for hours
  • > unlike other, occurs in mitochondria not cytoplasm