Lecture 5: The Circulatory System Flashcards

Better to check the notes.

1
Q

What is the function of the heart?

A

The heart pumps blood through blood vessels to all parts of the body

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2
Q

More specifically, the functions of the heart does two things:

A

1-delivers oxygen and nutrients to cells and tissues
2- Remove carbon dioxide CO2 and other waste products from cells and tissues

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3
Q

What composes the heart wall ?

A

myocardium

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4
Q

What is myocardium?

A

a layer of cardiac muscle forming the heart wall

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5
Q

What type of muscle is the myocardium?

A

Cardiac muscle

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6
Q

Why is the myocardium of the left ventricle so much thicker than that of the right ventricle?

A

It has to pump blood to your entire systemic circuit. So there’s enough force and pressure to send blood throughout your entire body.

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7
Q

Is deoxygenated blood actually blue?

A

no

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8
Q

Specialized cardiac muscle cells are part of which system of the heart?

A

intrinsic conduction system

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9
Q

What does self-excitable mean?

A

Can contract without signals from the nervous system

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10
Q

what do veins do?

A

They carry blood towards heart

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11
Q

what do arteries do?

A

They carry blood away from heart

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12
Q

Which parts of the heart are veins?

A

-Superior vena cava
-inferior vena cava
-pulmonary veins

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13
Q

Which parts of the heart are arteries?

A

-pulmonary trunk
-aorta

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14
Q

What is the function of atrioventricular valves?

A

To prevent blood flow from ventricle to atrium.

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15
Q

What is the function of chordae tendinaea ( heart strings)?

A

help flaps to anchor themselves and remain closed

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16
Q

What is the function of semilunar valves?

A

To prevent blood flow from arteries (aorta and pulmonary trunks)

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17
Q

What makes the sound of your heartbeat?

A

the blood hitting against your valves

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18
Q

What’s the name of the right atrioventricular valve?

A

tricuspid valve

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19
Q

What’s the name of the left atrioventricular valve?

A

bicuspid valve

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20
Q

Do av valve close or open when ventricles contract and relax?

A

they close when ventricles contract and open when ventricles relax

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21
Q

Where do we find or what are the two types of semilunar valves?

A

pulmonary and aortic

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22
Q

Do semilunar valves close or open when ventricles contract and relax?

A

opposite of av valves.

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23
Q

what do av valves prevent?

A

the flow of blood from ventricle to atria

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24
Q

what do semilunar valves prevent?

A

the flow of blood from arteries (pulmonary trunk and aorta) to ventricles

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25
Q

The heart is acting as two individual pumps: name them.

A

pulmonary (poumon) and systemic (système) circuit pump

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26
Q

True or False: Pulmonary and systemic circuits pump at alternate times.

A

False, they pump at the same time.

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27
Q

True or False: The blood flows through the pulmonary and not the systemic circuit with every heart beat.

A

False, pulmonary and systemic

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28
Q

What is right heart failure called? What is it?

A

peripheral congestion, fluid accumulation in the body tissues (more in the feet, ankles and fingers) and the build up of blood in the systemic circuit (congestion)

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29
Q

What is left heart failure? What is it?

A

pulmonary congestion, fluid accumulation and swelling in the lungs and back up (overflow) of blood in the lungs

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30
Q

What is the cardiac cycle?

A

1 complete heartbeat

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31
Q

what is systole?

A

heart contraction

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32
Q

what is diastole?

A

heart relaxation

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33
Q

Which part of the heart does most of the pumping work?

A

the ventricles

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34
Q

Explain the cardiac cycle.

A

1- atrial and ventricular diastole
2-atrial systole and ventricular diastole
3-atrial diastole and ventricular systole
-ventricles contract
-av valves closes
-semilunar valves open
-blood flow from ventricles into aorta and pulmonary trunk

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35
Q

What controls each heartbeat?

A

specialized self-excitable cardiac muscle cells that are part of the intrinsic conduction system of the heart.

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36
Q

what does self-excitable mean?

A

can contract without signals from the nervous system

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37
Q

true or false: cells of the cardiac conduction system have different intrinsic rates of contraction.

A

true

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38
Q

Why do we need the SA node?

A

Or else it will be out of sync. we need coordinated contractions. it sets the pace of the heart.

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39
Q

What’s special about the SA node?

A

it has the highest rate of depolarization (muscle contraction) and sets the pace for the entire heart. It is the pacemaker.

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40
Q

Cardiac muscle cells are electrically coupled by______ (contain gap junctions) between adjacent cells

A

intercalated disks

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41
Q

what do gap junctions do?

A

they connect cytoplasm of 2 cells

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42
Q

What causes contractions?

A

Electrical impulses and depolarization of muscle cells

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43
Q

Why is it pausing at the AV node?

A

To make sure the atria have enough time to contract and to fully empty

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44
Q

How does an artificial pacemaker work?

A

Sends electric shocks to the heart

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45
Q

Why would someone need an artificial pacemaker?

A

If there is an issue with your pacemaker

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46
Q

What do implanted electrodes do?

A

send electrical impulses to cardiac muscle cells to regulate heart rate.

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47
Q

What are the factors that affect heart rate?(4)

A

1- two sets of nerves act on the SA node to increase or decrease heart rate.
2- hormones
3-body temperature
4- exercise

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48
Q

How does two sets of nerves affect HR?

A

1- sympathetic nerves= increase HR
2- parasympathetic nerves= decrease HR

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49
Q

How do hormones affect HR?

A

1-Epinephrine= increase HR
2- Thyroid hormones= increase HR

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50
Q

How does body temperature affect HR?

A

-High body temp= increase HR
-Low body temp= decrease in HR

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51
Q

How does exercises affect HR?

A

HR increases in response to exercise (increases metabolic needs to body)

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52
Q

What does ECG stand for?

what is it?

A

Electrocardiogram (flow of electricity through heart)

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53
Q

True or False: Cells do not need to depolarize before they can be depolarized again

A

False

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54
Q

What is P-wave?

A

Depolarization of SA node and atria

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55
Q

What is QRS complex?

A

Ventricular depolarization

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56
Q

What is T-wave?

A

Ventricular repolarization

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57
Q

Where is atrial repolarization?

A

masked by QRS

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58
Q

Where does the AV node fire?

A

somewhere between P and Q

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59
Q

What is fibrillation or V-Fib?

what causes it?

A

Lack of adequate blood supply to heart caused by myocardial infarction that can cause V-Fib, an uncontrolled shuddering of the heart, making the heart useless as a pump.

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60
Q

what stop fibrillation? How?

A

Defibrillators stop fibrillation by delivering an electric shock that “resets” the heart.

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61
Q

What do arteries do?

A

They carry blood away from heart (toward capillaries)

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62
Q

What do arteries branch into?

A

arterioles

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63
Q

what do veins do?

A

carry blood toward the heart (away from capillaries)

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64
Q

What converges into veins?

A

Venules

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65
Q

What are capillaries?

A

-site of exchange (blood-tissue; tissue-blood)
-upstream end branches from arterioles
-downstream end converges into venules

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66
Q

What are the three main layers of artery and veins?

A

1-Tunica intima
2-Tunica media
3-Tunica externa

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67
Q

What is the tunica intima composed of?

A

1-Endothelium (simple squamous epithelium)
2-Subendothelial layer
3- Internal elastic membrane

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68
Q

What is the tunica media composed of?

A

1- smooth muscle
2- elastic fibers
3- External elastic membrane

69
Q

what is the tunica externa composed of?

A

1-collagen fibers (connective tissue)
2-Vasa vasorum

70
Q

Why is the tunica media important?

A

Important for regulating the diameter of the vessel and supporting the pressure

71
Q

capillaries consists only of which layer?

A

tunica intima

72
Q

What differences do you notice between arteries and veins?

A

-The smooth muscle layer is much thicker in the artery than in the vessel
-The shape of the artery is circular while the veins don’t have as much structure so they collapse more easily since less smooth muscle

73
Q

Where does exchange with tissue happen?

A

In the capillaries (only)

74
Q

What type of tissue lines the tunica intima?

A

the simple squamous epithelium

75
Q

what does tunica intima do?

A

They minimizes resistance to blood flow

76
Q

what is the purpose of tunica media?

A

for strength, movement and elasticity

77
Q

What is the purpose of tunica externa?

A

For support and protection

78
Q

What is the difference between the arteries and veins in the lumen? what’s the reason?

A

The lumen is larger in veins because of low peripheral resistance ( low pressure= easier to go to heart)

79
Q

What is the difference between the arteries and veins in the tunica media? what’s the reason?

A

The tunica media is thicker in the artery to withstand high pressure

80
Q

What is the difference between the arteries and veins in the tunica externa? what’s the reason?

A

The tunica externa is thicker veins to provide support since they don’t have a thick layer of smooth muscle

81
Q

What is the difference between the arteries and veins in the elastic lamina? what’s the reason?

A

Elastic lamina is only found in arteries to withstand high pressure.

82
Q

What is the difference between the arteries and veins in the valves? what’s the reason?

A

Valves are only found in veins to facilitates return of blood to heart ( prevents back flow)

83
Q

Does blood pressure decreases as blood travels away from the heart ventricles? Why?

A

yes, because it counteracts resistance

84
Q

What does the contraction of skeletal muscles provides ?

A

a “milking” action to push blood back to the heart

85
Q

Valves close to ensure what?

A

blood only moves in one direction (towards the heart)

86
Q

Where does blood flow the slowest through? Why?

A

Slow flow in the capillaries to enhance exchange

87
Q

How is blood pressure measured?

A

The hydrostatic force that blood exerts on the vessel walls.
The force pushing against the wall of the vessel walls.

88
Q

What keeps blood moving?

A

The pressure gradient provides driving force from high pressure to low pressure.

89
Q

Are we measuring venous or arterial blood pressure?

A

Arterial because we get valuable information since pressure is very present.

90
Q

What’s the normal blood pressure?

A

120/70-80 mm Hg

91
Q

Systolic pressure is created by__?

A

ventricles contracted (high blood pressure)

92
Q

diastolic pressure is created by__?

A

ventricles relaxed (low blood pressure)

93
Q

What happens when blood pressure is too high?

A

could cause a stroke ( blood vessel damage)

94
Q

What happens when blood pressure is too low?

A

lose consciousness (inadequate tissue perfusion)

95
Q

What is used to measure blood pressure?

A

sphygmomanometer

96
Q

where do you break the flow of blood?

A

in the brachial artery

97
Q

How can heart rate be measured?

A

indirectly by measuring pulse

98
Q

What is a pulse?

A

pulse is the rhythmic stretching of arteries caused by contraction of the ventricles

99
Q

What causes the arteries to stretch?

A

peripheral resistance in arterioles

100
Q

how does peripheral resistance in arterioles causes the arteries to stretch?

A

it impedes (prevent) blood from exiting the arteries

101
Q

What are the four factors affecting blood pressure?

A

1- peripheral resistance
2-cardiac output
3- blood volume
4- vessel elasticity

102
Q

what does peripheral resistance depends on?

A

blood viscosity
total blood vessel length
blood vessel diameter

103
Q

what determines the diameter of the arterioles?

A

the vasocontriction/vasodilation of arterioles which is controlled by action of nerve impulses, hormones and other chemicals on the smooth muscle surrounding the vessels

104
Q

what does nitric oxide do?

A

it causes vasodilation (it lowers blood pressure)

105
Q

what does endothelin do?

A

it causes vasoconstriction (it increases blood pressure)

106
Q

how does stress affect arterioles?

A

stress will cause vasoconstriction

107
Q

what is the effect of cardiac output on blood pressure?

A

an increase of cardiac output= increases pressure

108
Q

what is the effect of blood volume on blood pressure?

A

increase in blood volume= increase pressure

109
Q

what is the effect of vessel elasticity on blood pressure?

A

less elasticity= higher pressure (ex: arteriosclerosis)

110
Q

Cardiac output depends on 2 variables:___

A

1- stroke volume (volume of blood pumped out by ventricles during each contraction)
2- heart rate

111
Q

how does stress affect blood pressure?

A

more stress= increase blood pressure

112
Q

how can you exercise without passing out or having a stroke?

A

during exercise, increase in cardiac output and decrease in peripheral resistance.

113
Q

If blood pressure is low in veins compared to arteries, how can venous return= cardiac output?

A

resistance of arterioles and capillaries dissipates (make disappear) the pressure generated by the pumping heart

114
Q

What are the three factors that increase venous return?

A

1- skeletal muscle pump
2-Respiratory pump
3-Lumens of veins are wider than arteries

115
Q

how does skeletal muscle pump increase venous return?

A

skeletal muscles and valves provide a ‘milking’ action to keep blood moving towards the heart.

116
Q

how does respiratory pump increase venous return?

A

When breathing, the thoracic cavity decreases and the pressure in vena cava and right atrium decreases

117
Q

how does lumens of veins increase venous return?

A

wider= less resistance to flow/ low peripheral resistance

118
Q

What also account for some movement of blood?

A

Rhythmic contractions of smooth muscle in the walls of veins and venules

119
Q

What is the smallest blood vessels in the body?

A

capillaries

120
Q

how much at any given time does you capillaries have blood flowing through them?

A

5-10%

121
Q

which parts of the body are usually filled to capacity?

A

brain, liver capillaries, heart, kidney

122
Q

Who controls the flow of blood through capillary beds?

A

constriction of arterioles and precapillary sphincters (rings of smooth muscle)

123
Q

What would blood flow look like right after a meal?

A

more blood flow to digestive system

124
Q

True or False: blood cells and proteins cross the capillary.

A

False, they are too large to cross (and should not)

124
Q

How do molecules cross capillaries?

A

bulk flow through clefts between endothelial cells due to fluid pressure

125
Q

What does the amount and direction of fluid flow depends on?

A

1- hydrostatic pressure: fluid pressing against wall (due to blood pressure) “pushing out”
2- osmotic pressure: non-diffusible plasma proteins pull water into capillary “sucking in”

126
Q

how much do venous end reabsorb fluid?

A

85% of fluid is reabsorbed

127
Q

Where does the remaining 15% of fluid go?

A

They are returned to the blood via the lymphatic system

128
Q

What is the difference between the lymphatic and cardiovascular system?

A

lymphatic is not a circuit. It just cuts off in places. They intermingle amongst capillaries and vessels

129
Q

how are fluids that leak from the capillaries into the ISF returned to the blood?

A

by the lymphatic system

130
Q

what flows through a network of lymphatic vessels and has a composition similar to ISF?

A

Lymph

131
Q

Where does the lymphatic system drain into?

A

the cardiovascular system via the subclavian veins.

132
Q

How does fluid enter the lymphatic system?

A

by diffusing into lymphatic capillaries

133
Q

In the lymphatic system, what do valves and skeletal muscle do?

A

valves= prevent back flow
skeletal; muscle= pushes fluid towards the heart

134
Q

What are lymph nodes?

A

bean-shaped organs located at intervals along the lymphatic system ( filled with white blood cells)

135
Q

What is the function of plasma?

A

it carries blood cells, cell fragments, nutrients, metabolic wastes, respiratory gases, and hormones around the body.

136
Q

What is the composition of plasma?

A

1-90% water
2- Ions (electrolytes)
3- Plasma proteins

137
Q

what do ions do?

A

-osmotic balance
-functioning of muscles and nervous system
-pH buffering

138
Q

what do plasma proteins do?

A

-osmotic balance
-pH buffering
-viscosity of blood
-Transport of water insoluble lipids
-immunity (antibodies)
-blood clotting (ex: fibrinogen)

139
Q

What is plasma without clotting factors called?

A

serum

140
Q

What is the structure of erythrocytes?

A

-biconcave disc ( to increase surface area to transport and carry stuffs)
-no nuclei (more space for hemoglobin)
-no mitochondria
-contains 250 million molecules of hemoglobin

141
Q

each hemoglobin is made of how many protein?

A

made of 4 polypeptides that can bind 4 molecules of O2.

142
Q

what form part of the heme group? what does it bind?

A

iron atoms form part of the heme group that binds oxygen

143
Q

what does hemoglobin bind?

A

oxygen and nitric oxide

144
Q

what does nitric oxide cause?

A

it causes vasodilation which relaxes capillary walls to help delivery of O2 into cells

145
Q

What are the functions of leukocytes?

A

1- effectors of the immune system (fight pathogens)
2- spend most of the time patrolling the interstitial fluid and lymphatic system

146
Q

what do neutrophils and monocytes do?

A

they phagocytes that engulf and digest bacteria and cell debris

147
Q

what do lymphocytes do?

A

develop into specialized B cells and T cells

148
Q

What are basophils and eosinophils involved in?

A

they are involved in the allergic response

149
Q

which white blood cells are part of granulocytes?

A

NEB
neutrophil, eosinophil, basophil

150
Q

which white blood cells are part of agranulocytes?

A

LM
lymphocyte, Monocyte

151
Q

what is the function of platelets?

A

blood clotting

152
Q

How is clotting initiated?

A

when endothelium of a vessel is damaged and connective tissue in the wall is exposed to blood.

153
Q

what is hemophilia? what does it cause?

A

An inherited defect in any step of the clotting process
causes excessive bleeding from even minor cuts and bruises

154
Q

what causes spontaneous clotting?

A

platelets clump with fibrin within a blood vessel forming a thrombus

155
Q

where are blood cells produced?

A

in bone marrow

156
Q

where do all cells develop from?

A

pluripotent stem cells in the red marrow of bones

157
Q

what is leukemia?

A

a type of blood cancer involving the elevated production of abnormal white blood cells.

158
Q

what are the treatments of leukemia?

A

-to destroy a patient’s bone marrow and replace it with bone marrow from a healthy person.

159
Q

what is arteriosclerosis?

A

the thickening and hardening of an artery wall.

160
Q

what is the process of atherosclerosis?

A

1- plaques develop in the inner wall of the artery

2- (plaque) formation is due to an inflammatory response that is initiated by deposition of lipoproteins in the vessel wall

3- the process takes several years and causes the vessel to narrow down and harden

4-plaques can rupture and promote the formation of a thrombus

161
Q

what are the risk factors of atherosclerosis?

A

1- hypertension
2- LDL decrease and HDL increase

162
Q

what is a heart attack?

A

the death of cardiac muscle tissue caused by prolonged blockage of one or more coronary arteries

163
Q

what is a stroke?

A

the death of nervous tissue in the brain caused by the blockage of an artery or a leaking/burst blood vessel in the brain

164
Q

In both a heart attack and stroke tissue dies due to lack of _____.

A

oxygen

165
Q

what is angina pectoris?

A

If a coronary artery is partially blocked, a person may feel occasional chest pain because part of the heart is not receiving enough blood.

166
Q

What substance forms a mesh to trap RBCs and platelets in the clotting process?

A

Fibrin

167
Q

what is the main characteristic of hemophilia?

A

excessive bleeding

168
Q

what prevents spontaneous clotting?

A

anticlotting factors