Lecture 5 Part 1 Flashcards
is hepatitis A acute or chronic
acute
is hepatits B acute or chronic
can be either, but is acute most of the time
is hepatits C acute or chronic
chronic
is hepatitis E acute or chronic
usually acute. very rarely becomes chronic
true or false
most hepatitis viruses have a specific tropism for the liver
FALSE – all do
true or false
ALL hepatitis viruses replicate in hepatocytes
true
true or false
each hepatitis virus comes from a distinct individual family of viruses
true
name the virus for HAV (hepatitis A)
picornavirus (RNA+)
name the virus for HBV (hepatitis B)
hepadnavirus (dsDNA)
name the virus for HCV (hepatitis C)
flavivirus (RNA+)
name the virus for HDV (hepatitis D)
delta virus (RNA-)
name the virus for HEV (hepatitis E)
calicivirus (RNA+)
what are the most common hepatitis viruses
A,B,C
For which hepatitis viruses is there a vaccine?
hepatitis A, B, and D
which hepatitis viruses are transmitted primarily through the fecal oral route
A and E
which hepatitis viruses are most commonly transmitted via the parenteral route
B and C
can hepatitis D result in a chronic infection?
yes
50-70% of the time
which hepatitis virus is a major cause of infectious hepatitis
hepatitis A
HAV reaches the liver via…..
hepatic portal system
is hepatitis A oncogenic
no
HAV is cleared by what cells
NK cells, cd8 t cells, antibodies
name 4 symptoms of hepatitis A
fever anorexia jaundice nausea
explain the movement of HAV
slowly replicates in hepatocytes
shed into bile to small intestive via the bile duct
shed in the stool 10 days before symptoms occur
HAV is transmitted via the ____ but infects the ____. what can you conclude from this?
transmitted via the oral fecal route (picornavirus) yet infects the liver. therefore, it travels through viremia – gets to liver through hepatic portal system
what goes up to signal hepatic cell injury, and thus viral infection? (hepatitis)
alanine aminotransferase
true or false
hepatitis A can be seen in the feces before it ever gets to the liver
true
which virus makes DECOYS? what do these decoys consist of?
hepatitis B
consists of the dane particle with hepatitis B surface antigen (HBsAg) ONLY with no nucleic acid inside
how is hepatitis B virus unique in what it contains?
it’s a DNA virus that contains reverse transcriptase. replicates itself through an RNA intermediate
do humans encode a reverse transcriptase?
no
how is hepatitis B transmitted?
in bodily fluids
does HBV often result in chronic infection?
NO — sometimes
true or false
hepatitis B can be symptomatic or asymptomatic
true
what is the name of the hepatitis B surface antigen
HBsAg
what is the name of the hepatitis B CORE antigen? what does it do?
HBcAg
forms the ICOSAHEDRAL CAPSID for hepatitis B
WHY does HBV give minimal cytopathix damage?
it slowly replicates in the hepatocytes
what is HBeAg used as?
not really clear — used as a marker
what are the antibodies produced in response to
HBsAg
HBcAg
HbeAg
anti-Hbs
anti-Hbc
anti-Hbe
what is the name for the hepatitis b surface antigen and what does it consist of
HBsAg
3 polypeptides—- L M S
true or false
HBV does NOT contain protein kinase
FALSE — it does
dane particle consists of…
S plus some M antigen
explain the structure of DNA in HBV
double strand with a gap
when a new HBV virus is released from a cell, what comes with it?
HBsAg is released with the decoys
HBeAg is also released (glycoprotein marker)
what enzyme destroys the RNA in an RNA DNA hybrid when making new HBV?
rnase H
chronic, active HBV infection eventually reaches…
a plateau
