Lecture 5 Lymphatic System Flashcards
What does lymphatic system consist of?
Lymph vessels, lymphatic organs, diffuse lymphatic tissue
Function of lymph vessels?
- collection of tissue fluid and its return to the systemic circulation.
- Transport of lymphocytes and other cells.
What is tissue fluid in lymph vessels?
Tissue fluid is basically plasma (water, proteins, lipids extruded from blood capillaries into the connective tissue matrix. 20% (approx) of this fluid (lymph) is returned to the main systemic circulation via lymph vessels (80% approx. is removed blood capillaries, perspiration). If fluid/protein return is compromised then lymphoedema results.
Describe the return of lymph to venous system
Majority of return occurs in two places - at junctions of subclavian and internal jugular veins (usual pattern). There are additional connections into the venous system in the inferior vena cava and renal, suprarenal, azygous and iliac veins. The extent and location of these are variable and not fully documented but they are important if the usual lymph channels are blocked or damaged. Conversely they are also involved in the spread of malignancy or infection.
Describe general features of lymph vessels
- Lymph capillaries arise as blindly ending tubes in connective tissue which are initially a plexus then anastomose to form larger vessels.
- Particularly permeable, more so than blood capillaries
- Always small - largest - thoracic duct - is a few mm in diameter. All very thin walled.
- Many anastomoses
- Transport of fluid is slow. Mechanism similar to veins (muscle in walls, external pressures, gravity, lots of valves)
- May form plexuses on larger blood vessels
- Not found in cartilage and healthy non-inflamed human corneas.
- often but not always associated with lymph nodes
Function of lymph nodes
- Immunosurveillance of lymph
- production of lymphocytes and other immune cells
Describe general features of lymph nodes
- Organs 1-25mm long. Many are tiny. Lymph node enlargement is called lymphadenopathy and is the result of infection or a tumour.
- Nodes are always associated with lymph vessels.
- Contains proliferative structures - lymph nodules which produce lymphocytes and other immune cells, immunosurveillance of lymph.
Describe lymph nodules and their locations
- 300-400 nodes with most in neck, thorax, abdomen, pelvis, groin. Relatively few in limbs. However most medium to large lymph vessels pass through at least one node on their way back to the circulation (some exceptions - e.g. thoracic duct).
- Named according to whether they are superficial or deep and on the basis of associated structures.
- Other lymph organs include spleen, thymus and tonsils - only tonsils form part of this course.
List the trunks and branches of left side and lower body
- Thoracic duct
- 2 Lumbar trunks
- 1 Gastrointestinal trunk
- 2 descending intercostal (thoracic) trunks
- Left subclavian trunk
- Left jugular
- Left bronchomediastinal
- Cysterna chyli
Describe thoracic duct
Commonly formed by the confluence of 5 major tributaries in the posterior abdomen. Cysterna chyli may be present at confluence.
2 Lumbar trunks drains?
Drains lower abdominal and pelvic walls, lower limbs, pelvic viscera and parts of large intestine, kidneys and suprarenals.
1 Gastrointestinal trunk drains?
Drains liver, spleen, pancreas, stomach, small intestine and much of large intestine.
2 descending intercostal (thoracic) trunks drains?
Drains lower thoracic regions on both sides. These trunks pass down through diaphragm to the start of the thoracic duct.
The thoracic duct also receives lymph from ?
From a range of lymph vessels in the thorax.
In the neck, the thoracic duct has the following main tributaries:
- left subclavian trunk
- left jugular
- left bronchomediastinal
Left subclavian trunk drains from?
From left upper limb
Left jugular drains from?
From left head and neck
Left bronchomediastinal drains from?
Upper left thorax
Termination of thoracic duct is at?
Left jugulosubclavian junction
Right jugular, subclavian, bronchiomediastinal trunks drain from?
Right arm, right half of head and neck, upper right thorax.
Right subclavian, jugular and bronchomediastinal trunks drain?
Similar territories as on the left.
In about 20% of individuals, right subclavian, jugular and bronchomediastinal trunks converge to form?
Right lymphatic duct (approx 1 cm long) which drains into the right jugulosubclavian junction.
The thoracic duct and the right lymphatic duct have bicuspid valves at their terminations at the jugulosubclavian junctions which prevents or reduces regurgitation of blood in life.
True
The valve is still functional after death so regurgitation of blood then occurs.
False, it is non-functional.
Subclavian, jugular trunk and bronchomediastinal trunks have valves at their terminations.
False, only jugular trunk doesn’t have it.