Lecture 5: Hemoglobin Flashcards
1
Q
What causes methemoglobinemias?
A
Oxidation of the heme part in hemoglobin
2
Q
Congenital causes of methemoglobin?
A
Deficiency in NADH cytochrome B5 reductase
3
Q
What characterizes methemoglobin?
A
Chocolate cyanosis
4
Q
What is the treatment of methemoglobinemia?
A
Methylene Blue
5
Q
What causes B thalassemia?
A
When the B globin synthesis is defective as a result of point mutation that affect mRNA
6
Q
What are the 2 increases in hemoglobin?
A
HBA2 and HBF
7
Q
When does Cooley anemia occur?
A
When both genes are defective
8
Q
When is silent carrier A thalassemia?
A
When one gene is defective
9
Q
When is A thalassemia trait?
A
When 2 genes are defective
10
Q
When is HB4 disease?
A
When 3 are defective
11
Q
When is Hemoglobin Bart y4?
A
When all four are defective
