Lecture 24: Metabolism Of FFAs Flashcards by Ibrahim El-Mahdy | Brainscape

Q

What are the end products of lipolysis?

A

Glycerol and FFAs

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Q

What is the pathway for catabolism of FFA called?

A

B-Oxidation

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Q

What is fatty acyl CoA reduced to?

A

Acetyl CoA + NADPH + FAPH2

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Q

When is B-Oxidation increased?

A

When fasting or on ketogenic diet

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Q

Which chains can enter the mitochondria easily?

A

Short and medium

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Q

How does Long chain FAs enter the mitochondria?

A

Via carnitine shuttle

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Q

What enzyme acts on transfering the acyl group from CoA to carnitine?

A

CPT-1

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Q

What does Malonyl CoA inhibit?

A

CPT-1

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Q

What does Malonyl CoA not inhibit?

A

Medium chain FAs’

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Q

What is fatty acid oxidation regulated by?

A

Acetyl CoA/CoA ratio

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Q

What causes carnitine deficiency?

A

Valproic acid

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Q

What does carnitine deficiency present as?

A

Severe hypoglycemia

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