Lecture 26: Cardiac Metabolism Flashcards
1
Q
What are the 2 regulators of glucose uptake?
A
GLUT-1 and GLUT-4
2
Q
When glucose enters the cell, what happens?
A
It is rapidly phsophorylated via Hexokinase to form glucose 6-phosphate
3
Q
What are glucose and lactate converted to?
A
Pyruvate
4
Q
What cycle is the pyruvate oxidized in?
A
CAC
5
Q
What is Randle’s cycle?
A
The rate of FFA concentration is inverse to the rate of carbohydrate oxidation
6
Q
What do FFA oxidation and ketone bodies inhibit?
A
Activity of PDH
7
Q
What is the effect of insulin on carbohydrate metabolism in the heart?
A
Increases glucose uptake via GLUT-1 and GLUT-4 stimulation
8
Q
What is the effect of insulin on FFAs’?
A
Decreases their release and uptake
