Lecture 5 - Antihistaminics Flashcards
What is does APC stand for? And what is another name for it?
antigen presenting cell; dendritic cell
Is the response innate or adaptive?
- no prior exposure, killer-T, macrophages and the response time is <12hrs
innate
Innate or adaptive?
specific prior exposure present. Memory B&T cells, long term memory, 1-2 wks.
adaptive
Which type?
Atopy, asthma, anaphylaxis
Type 1 hypersensitivity (allergy)
An exaggerated immune response specifically involving an innate or foreign innocuous antigen classified as an allergen.
hypersensitivity
Which type?
Graves, MG, autoimmune diseasee
Type 2 (antibody mediated or cytotoxic)
Which type?
Arthritis, nephritis, vasculitis, SLE
Type 3 (immune complex)
Which type?
allergy (conjnctivitis medicamentosa, contact dermatitis, chronic transplant rejection, IDDM, MS, RA)
Type 4 (deployed [CD4] and/or cell-mediated [CD8])
Which hypersensitivity type?
B-cell + allergen –> IgE –> tissue/blood
type 1 hypersensitivity
Topical antihistaminic/MCS combo drugs Generic: ketotifen maker: B&L Ped Use: 3y Dosing: Bid
Alaway
Topical antihistaminic/MCS combo drugs Generic: bepotastine maker: ISTA Ped use: 2 yeear Dosing: Bid
Bepreve
Topical antihistaminic/MCS combo drugs generic: epinastine maker: Allergan ped use: 3 year dosing: Bid
Elestat
Topical antihistaminic/MCS combo drugs generic: alcaftadine maker: Allergan Ped use: 2 year Dosing: Qd
Lastacaft
Topical antihistaminic/MCS combo drugs generic: azelastine maker: meda Ped Use: 3 year dosing: Bid
Optivar
Topical antihistaminic/MCS combo drugs generic: olopatadine maker: Alcon Ped Use: 3 year Dosing: Qd
Pataday
