Lecture 1 - Intro

Question 1

Potential for drug-receptor binding.

Answer 1

Affinity

Question 2

Binding site w/ biological effect.

Answer 2

Receptor

Question 3

Capacity to produce a biological effect.

Answer 3

Intrinsic activity

Question 4

Having intrinsic activity and affinity.

Answer 4

Agonist

Question 5

Affinity without intrinsic activity.

Answer 5

Antagonist

Question 6

A stereospecific phenomenon whereby a bound ligand influences specificity of a second site

Answer 6

Allostery

Question 7

Efficacy

Answer 7

[affinity] x [intrinsic activity]

Question 8

‘effective’ concentration in 50% of subjects

Answer 8

EC50

Question 9

‘effective’ dose in 50% of subjects

Answer 9

ED50

Question 10

‘inhibitory’ concentration in 50% of subjects

Answer 10

IC50

Question 11

Result in chronic antagonism.

Answer 11

hypersensitivity

Question 12

minimum amount of drug producing maximum therapeutic effect

Answer 12

maximum dose

Question 13

Low intrinsic activity with potency and affinity within therapeutic range.

Answer 13

partial agonist

Question 14

Drug –> Body

Answer 14

Pharmacodynamics

Question 15

Body –> Drug (ADME)

Answer 15

Pharmacokinetics

Question 16

Drug –> Disease

Answer 16

Pharmacotherapeutics

Question 17

Science of drug dosing

Answer 17

Posology

Question 18

response to a give dose

Answer 18

Potency

Question 19

Loss of pharmacological effect.

Answer 19

Resistance

Question 20

Ability to produce a desired effect versus adverse effect.

Answer 20

Selectivity

Question 21

Ability to act at a specific receptor.

Answer 21

Specificity

Question 22

Rapidly decreasing therapeutic response.

Answer 22

Tachyphylaxis

Question 23

congenital malformation

Answer 23

Teratogenesis

Question 24

Amount of active drug reaching target tissue.

Answer 24

Bioavailability

Question 25

LD50:ED50 or TD50:ED50

Answer 25

therapeutic index

Question 26

Diagnostic pharmaceutical agent

Answer 26

DPA

Question 27

Therapeutic pharmaceutical agent

Answer 27

TPA

Question 28

insulin

Answer 28

Supplemental drug type

Question 29

glucose

Answer 29

Supportive drug type

Question 30

low dose aspirin

Answer 30

Prophylactic drug type

Question 31

fluorescein

Answer 31

Diagnostic drug type

Question 32

Methotrexate

Answer 32

Therapeutic drug type

Question 33

Tear film

Answer 33

~10ul

Question 34

max surface area

Answer 34

~30 ul

Question 35

gt?

Answer 35

25-56 ul

Question 36

Basal tear flow

Answer 36

0.5-2.2 ul/min

Question 37

cornea in diabetes

Answer 37

thick

Question 38

cornea in keratoconus

Answer 38

thin

Question 39

Concentration independent; rate limiting barrier or saturable carrier; constant amount of clearance; elimination per unit time is linear

Answer 39

Zero order

Question 40

Concentration dependent; non-saturable carrier; constant proportion of clearance & constant half-life; elimination per unit time is exponential

Answer 40

1st order (most drugs)

Question 41

saturable carrier at high concentrations only

Answer 41

mixed-order

Question 42

High abuse, no known medical use, lack of safety

Answer 42

Schedule 1 Drug; unavailable like heroin

Question 43

High abuse, some medical use, high risk of dependency

Answer 43

Schedule 2 Drug; morphine

Question 44

Lower abuse, medical use, moderate dependency risk

Answer 44

Schedule 3 Drug; valium

Question 45

Limited abuse, high medical use, limited dependency risk

Answer 45

Schedule 4 Drug; codeine

Question 46

Minor problems, may be available w/o Rx

Answer 46

Schedule 5 Drug; penicillin

Question 47

No evidence of risk in women.

Answer 47

A

Question 48

No evidence of risk in animals.

Answer 48

B

Question 49

Animal toxicity evidence

Answer 49

C

Question 50

Risk may equal benefits

Answer 50

D

Question 51

Risk > benefits

Answer 51

X

Question 52

Off-label drug use

Answer 52

Practice of prescribing a drug for a non-FDA approved indication