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Ocular Pharmacology > Lecture 4 - Mydriatics Cycloplegics > Flashcards

Lecture 4 - Mydriatics Cycloplegics Flashcards

1
Q

Hormones including dopamine, epinephrine and norepinephrine; produced from tyrosine in postganglionic fibers of the autonomic nervous system and the adrenal medulla

A

Catecholamines

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2
Q

Catechol-O-methy transferase; an enzyme of catecholamine metabolism

A

COMT

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3
Q

Monoamine oxidase; an enzyme of catecholamine metabolism

A

MAO

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4
Q

Pupillary contraction

A

miosis

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5
Q

Pupillary dilation

A

mydriasis

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6
Q

Paralysis of the ciliary body musculature responsible for accommodation.

A

cycloplegia

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7
Q

Which Ig in the bloodstream reacts with the antigen leading to histamine release, bronchoconstriction, vasodilation and swelling?

A

IgE

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8
Q

Fight and Flight is regulated by the __________ or ____________ branch of the ANS.

A

Sympathetic/adrenergic; autonomic nervous system

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9
Q

Rest and Digest is regulated by the ___________ or ____________ branch of the autonomic nervous system.

A

Parasympathetic / cholinergic

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10
Q

Epinephrine and Norepinephrine are part of the ________ ANS NTs.

A

sympathetic

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11
Q

Presynaptic +a2 receptor stimulates/inhibits signal propagation

A

inhibits

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12
Q

Stimulation of a1: vasoconstriction/vasodilation

A

vasoconstriction

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13
Q

Stimulation of b2: vasoconstriction/vasodilation

A

vasodilation

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14
Q

Stimulation of b2 in lungs? dilation or constriction?

A

bronchodilation

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15
Q

Stimulation of b1 in heart: increase/decrease contractility and conduction.

A

increase contractility and conduction

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16
Q

In the liver stimulation of b2 causes?

A

glucogenolysis; break down of glycogen and dumping into the bloodstream

think of it facilitating fight/flight.

17
Q

In the pancreas stimulation of b2 causes increase/decrease in insulin release.

A

increase in insulin release

18
Q

In the pancreas stimulation of a2 causes increase/decrease in insulin release.

A

decrease in insulin release

19
Q

In the iris, stimulation of a1 causes _______.

A

mydriasis

20
Q

In the ciliary body stimulation of b2 causes constriction/relaxation and increase/decrease in aqueous production.

A

Relaxation and increase in aqueous production

21
Q

In the ciliary body stimulation of b2 or a2 causes increase/decrease in aqueous production.

A

decrease aqueous production

22
Q

What does a1 receptor respond to?

A

NE > E

23
Q

What does a2 receptor respond to?

A

E >/equal NE

24
Q

What does b1 receptor respond to?

A

E = NE

25
Q

What does b2 receptor respond to?

A

E

26
Q

Catecholamines comes from what amino acid?

A

tyrosine

27
Q

What is responsible for the liberation of DA (dopamine) and NE from the nerves vesicles?

A

Ca+2

28
Q

In the ocular system an increase in IOP, risk in angle closure, and allergic reaction are adverse effects of what?

A

anticholinergics

29
Q

The adverse effects of anticholinergics systematically are the ABCCDSS

A

Anorexia, Blur, Constipation & Confusion, Dryness, Sedation & Stasis of urine.

30
Q

In the CNS (medulla) you get a decrease in Parkinson tremor and HR by this cycloplegic drug.

A

Anticholinergics

31
Q

Which cycloplegic would have give with these indications?

mydriasis, dose-dependent cycloplegia, less pigment-sensitivity than cyclopentolate, homatropine and atropine,

A

tropicamide

Ocular Pharmacology (6 decks)

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