Lecture 5

Question 1

Pure drug?

Answer 1

Drug substance, medicinal agent, active ingredient, powder

Question 2

Drug and excipients?

Answer 2

Drug, product, medicinal product, formulation (primary + secondary packaging: tablet pack + box, licence for whole product)

Question 3

Dosage forms?

Answer 3

Oral: non sterile, patients needs to swallow
Rectal: non sterile
Topical: non sterile
Injection: sterile, tight quality control
Lungs: ease
Nasal: ease
Eye: sterile
Vaginal/urethral: ease

Question 4

Types of drug entry routes?

Answer 4

Intravenous (vein): various volumes, quick onset
Intramuscular: vaccines, small volume, onset 10 min
Sub-cutaneous (injection just under skin): pain relief, 15 min
Intra-peritoneal (injection into body cavity): Cancer treatments, small volumes, faster than SC
Intraosseous (into bone): emergency, quick onset
Intrathecal (into spine/CNS): epidural, small volume

Question 5

What needs to happen in order for drug to dissolve?

Answer 5

System has to create a gap before molecule can leave surface of crystal and diffuse into the gap (high energy transitional state), getting energy back when solvents attaches to solute