Lecture 2 Flashcards
Buccal cavity?
Mouth - teeth, tongue, salivary glands
Gingival mucosa?
Gums, keratinised/non polar
Palatal mucosa?
Roof of mouth, keratinised/non polar
Buccal mucosa?
Cheek/upper lip/lower lip, non keratinised/polar
Sublingual mucosa?
Floor of mouth (under tongue), non keratinised/polar
Major barrier to buccal drug delivery?
Oral mucosa
Whys is sublingual administration faster than buccal?
Closer to bloodstream, so faster onset of action
First pass metabolism?
Drugs metabolised in liver before they reach systemic circulation
Advantages of buccal delivery?
Avoids first pass metabolism and blood brain barrier, painless, good patient compliance, predictable drug concentration in blood
Disadvantages of buccal drug delivery?
Need for taste masking, hazard of choking, irritation of gums
Examples of buccal drug delivery?
Spray: glyceryl trinitrate
Lozenge: hydrocortisone
Sublingual tablet: desmopressin
Chewing gum: nicotine
Patch: dental anaesthesia, lidocaine
Gel: Bonjela
Tablet: Buccastem
“Glue” formulation to buccal surface?
“Glue” is typically as polymer that adheres to a biological surfaces (bioadhesion) or to the mucosal surface (mucoadhesion).
Checklist for “glue”?
Strong enough to hold the formulation (e.g., tablet).
Removable when treatment is complete.
Safe for oral application.
Permits drug diffusion
How does “glue” stick?
It becomes tangled in the glycoprotein surface of the cells, and bonds with glycoproteins (anionic - negatively charged - polymers are generally better than cationic - positively charged - or uncharged polymers)
