Lecture 4

Question 1

Drug?

Answer 1

Produces biological response, most are small molecules/not endogenous (not produced in body).

Question 2

Pharmacodynamics?

Answer 2

What drug does to body

Question 3

Pharmacokinetics?

Answer 3

What body does to drug

Question 4

Therapeutic window?

Answer 4

Desired response (MEC) up to toxic response (TC) - is the safe range

Question 5

Cyclo-oxygenase (COX)?

Answer 5

Initiates PG (prostglandin) synthesis cascade, PG synthesis increased at site of inflammation

Question 6

Competitors of COX?

Answer 6

Non steroidal anti inflammatory drugs (NSAIDs) e.g. ibuprofen = antagonist, forms stronger interactions with active site than arachidonic acid (substrate)

Question 7

B2 adrenoreceptors?

Answer 7

Activation initiated by adrenaline and noradrenaline which dilates airways

Question 8

B2A agonist (induces same response)?

Answer 8

Salbutamol - asthmatic patients breathe more easily.

Question 9

B2A antagonist?

Answer 9

Atenolol