Lecture 4 - basic concepts pt3 Flashcards
What is ultrarapid metabolizer?
- Normal or increased activity
- An individual carrying two increased activity alleles or one functional allele + one increased activity allele
What is extensive metabolizer?
- Homozygous wild type or normal activity
- An individual carrying two functional alleles
What is intermediate metabolizer?
- Heterozygote or intermediate activity
- An individual carrying one functional allele + one loss of function allele or one loss of function allele + one increased activity allele
What is poor metabolizer?
- Homozygous variant, mutant, low, or deficient activity
- An individual carrying two loss of function alleles
What is the allele frequency for a population of N individuals?
- Q number of persons w T/T
- R number of persons w T/C
- S number of persons w C/C
What is the equation to calculate the number of T allele?
2Q + R
What is the equation to calculate the number of C allele?
2S + R
What is the equation to calculate the frequency of T allele?
(2Q + R)/2N
What is the equation to calculate the frequency of C allele?
(2S + R)/2N
Calculate the allele frequency of lecture example.
How to figure out minor allele frequency (MAF) if genotype frequency are known?
What is a common/major/reference allele?
Allele with higher frequency (>50%)
What is rare/minor/mutant allele?
Allele with lower frequency (<50%)
Can a rare allele in one population can be a common allele in another population?
Yes
What is a haplotype?
Group of genes within an organism that were inherited together from a single parent
