Lecture 4 Flashcards
What does a hormone-secreting cell do?
Secretes hormones; can reach anywhere in your body through blood circulation but only the cells that have that hormone receptor (target cell)
Can have receptor for their own signal (can sense their own hormone)
What is a non-target cell?
A cell that a hormone can’t bind to
What are hormones?
One type of chemical signals that enter the blood and activate target cells far from the site of release
What are hormones secreted by?
Endocrine cells
What are hormones that are released by neurons called?
Neurohormones (These neurons act as endocrine cells)
Based on chemical properties, what are three categories of hormones?
Peptides or proteins, steroid hormones, amine hormones
Based on chemical properties, what are three categories of hormones?
Peptides or proteins, steroid hormones, amine hormones
What are peptide or protein hormones?
Water-soluble, easily transportable in blood (mixes well with water), receptors are on cell surface (polar–can’t pass lipid membranes easily)
What are steroid hormones?
Lipid soluble, need carrier proteins in blood (since it can’t mix with water), receptors are mostly intracellular
What are amine hormones?
Mostly synthesized from amino acid tyrosine, water or lipid soluble–receptors can be intracellular or on surface
Where do receptors for water-soluble hormones reside?
On the cell surface
Where do receptors for lipid-soluble hormones reside?
Intracellular; mostly regulate gene expression in nucleus
How do receptors for water-soluble hormones induce cellular response?
Via second messengers
How do receptors for water-soluble hormones induce cellular response?
Via second messengers
What is the effect of different receptors of a single hormone?
Diverse effects
What is fight-or-flight response mediated by?
Epinephrine
What are the effects of epinephrine?
Heart beats faster and stronger, blood vessels: more blood to muscle, constriction in skin, kidneys, digestive tract; releases glucose in liver (more energy); releases fatty acids (more energy)
What secretes epinephrine?
The adrenal gland
What secretes epinephrine?
The adrenal gland
Can endocrine cells exist as individual cells within a tissue? How else might they organize?
Yes (e.g., endocrine cells in digestive tract). May organize into secretary organs whose main function is to secrete different hormones (endocrine glands, not organs–e.g., pancreas)
What are secretary organs?
Endocrine glands that can secrete multiple hormones
What’s in the anterior pituitary/what’s it do?
Controlled by the hypothalamus, contains many hormones, controls other endocrine glands
Posterior pituitary
Hypothalamus releases hormones to this. Ex. oxytocin
Posterior pituitary
Hypothalamus releases hormones to this. Ex. oxytocin
What’s the pancreas important for?
Energy and homeostasis (e.g., insulin, glucagon)
Example of hormone in thyroid gland
Thyroxine
Example of hormones in adrenal gland
Cortisol, aldosterone, epinephrine, nonepinephrine
Examples of hormones in gonads
Testosterone, estrogen
What does white adipose tissue secrete?
Leptin–controls appetite
What was the 1st hormone ever discovered?
Secretin from the intestine
What is special about Vitamin D?
It acts as a hormone in the skin, not a vitamin
What is the central endocrine control?
Hypothalamus, pituitary glands
What is the central endocrine control?
Hypothalamus, pituitary glands (nodes of hypothalamus)
Posterior pituitary
Hypothalamus releases hormones to this. Ex. oxytocin
Has no cells that secrete hormones (cells come from hypothalamus)
What is the central endocrine control?
Hypothalamus, pituitary glands (nodes of hypothalamus)
What is a continuation of the hypothalamus?
Posterior pituitary
Where does the hypothalamus release neurohormones via?
The posterior pituitary
What is antidiuretic hormone (ADH, vesopressin)?
Increases water retention by the kidneys; not releasing too much urine
What is oxytocin?
Promotes bonding, stimulates uterine contractions (childbirth), milk flow, etc.
What is oxytocin?
Promotes bonding, stimulates uterine contractions (childbirth), milk flow, etc.
Ex. prairie voles (opposite: mountain voles–less receptors for the hormone)
How do things go from hypothalamus to posterior pituitary?
Long neuron cells from hypothalamus extend axons to posterior pituitary –> release neural hormones directly from posterior pituitary
What does the hypothalamus have control over?
The anterior pituitary
When does the anterior pituitary secrete hormones?
When hypothalamus tells them to (when it releases ___-releasing hormone). Hormones released can control other glands: tropic hormones
Where does the anterior pituitary come from?
Gut tissue
Examples of hypothalamus/anterior pituitary hormones
Thyrotropin-releasing hormone (TRH) - Thyrotropin (controls thyroid)
Gonadotropin-releasing hormone (GnRH) - gonadotropins (control gonads)
Corticotropin-releasing hormone (CRH) - Corticotropin (control adrenal cortex)
Examples of hypothalamus/anterior pituitary hormones
Thyrotropin-releasing hormone (TRH) - Thyrotropin (controls thyroid)
Gonadotropin-releasing hormone (GnRH) - gonadotropins (control gonads)
Corticotropin-releasing hormone (CRH) - Corticotropin (control adrenal cortex)
Growth hormone-releasing hormone (GhRH) - Growth hormone (non-tropic, promotes growth)
What is tropic?
Have other endocrine glands as targets
What is non-tropic?
Directly stimulates target cells to induce effects
What are examples of growth hormone defects?
Gigantism and pituitary dwarfism
What controls hormone secretion?
Negative feedback loop
What is the process of releasing a hormone?
External or internal conditions -> hypothalamus -> releasing hormone -> anterior pituitary -> tropic hormone -> endocrine gland -> hormone
What is the long loop negative feedback for hormone secretion?
Inhibit hypothalamus which inhibits the releasing hormone, thus inhibiting anterior pituitary and the tropic hormone. OR inhibit the anterior pituitary
What is the short loop negative feedback for hormone secretion?
Most likely there is too much tropic hormone, so inhibit hypothalamus to stop releasing hormone, which will stop the anterior pituitary
What does the thyroid gland produce and store?
Thyroxine and calcitonin
What is thyroxine?
A hormone in the thyroid gland that elevates metabolic rate so it’s important for development and growth (provides energy for our growth)
What does calcitonin stimulate?
Stimulates incorporation of calcium into bone
In thyroid gland
What is the negative feedback regulation of thyroxine?
External or internal conditions -> hypothalamus -> release of TRH (thyrotropin releasing hormone) -> anterior pituitary -> release of TSH (thyro
What is the negative feedback regulation of thyroxine?
External or internal conditions -> hypothalamus -> release of TRH (thyrotropin releasing hormone) -> anterior pituitary -> release of TSH (thyrotropin: thyroid stimulating hormone) -> thyroid -> thyroxine
What is goiter?
Enlarged thyroid gland. Affects 5% of world’s population. Caused by both hyperthyroidism (too much thyroxine) and hypothyroidism (too little thryoxine)
What is Grave’s disease?
An autoimmune disease (immune system attacks itself), high metabolic rates, feel hot, eyes bulge
What is Grave’s disease?
An autoimmune disease (immune system attacks itself), high metabolic rates, feel hot, eyes bulge
How does hyperthyroidism work in causing goiter?
Excess thyroxine means a higher metabolic rate, more heat generated, high storage of fat under eye. Antibody-binding from Grave’s disease activates TSH receptors on thyroid and increases thyroxine. Thyroid remains stimulated and grows bigger
How does hyperthyroidism work in causing goiter?
Excess thyroxine means a higher metabolic rate, more heat generated, high storage of fat under eye. Antibody-binding from Grave’s disease activates TSH receptors on thyroid and increases thyroxine. Thyroid remains stimulated and grows bigger. TRH and TSH both decrease because of negative feedback.
What is Cretinism?
low metabolism, intolerance to cold, physical and mental retardation
What is the most common cause of hypothyroidism?
Iodine deficiency –> can’t produce functional thyroxine
What is needed for thyroxine synthesis?
Iodine-T3 and T4. Majority of thyroxine is T4 but T3 is much more active than T4.
How do we solve the iodine deficiency?
Supply salt w/ iodine in countries lacking iodine
How does hypothyroidism work in causing goiter?
deficiency in thyroxine from iodine –> negative feedback loop keeps producing more TRH and TSH but the thyroid is still unable to produce thyroxine
How does hypothyroidism work in causing goiter?
deficiency in thyroxine from iodine –> negative feedback loop keeps producing more TRH and TSH but the thyroid is still unable to produce thyroxine
Where are the adrenal glands located?
On top of kidneys like little pets
What two glands make up the adrenal glands?
Cortex and medulla