Lecture 3 Flashcards
What are the three types of vertebrate muscle?
Skeletal, cardiac, and smooth
What types of movements are in each type of muscle?
Skeletal-voluntary (running, playing piano), some involuntary (breathing)
Cardiac-involuntary (beating of heart)
Smooth-involuntary (movement of internal organs)
What are the cells called of muscles?
Muscle fibers
What is a trait of muscle fibers?
Excitable (general action potential like neurons)
What is a trait of muscle fibers?
Excitable (general action potential like neurons)
What is the structure of cardiac muscle?
Cells electrically coupled, tightly joined to one another
What is the structure of smooth muscle?
Cells arranged in sheets in internal organs
What is the structure of skeletal muscle?
Long cells, striped structure like in cardiac (remember! striations)
What are striations?
The lines in the structure of skeletal muscle and cardiac muscle
What is the breakdown of the structure of skeletal muscle?
Muscle -> Bundle of muscle fibers -> Smaller bundle of muscle fibers (connective tissue) -> single muscle fiber (cell but long and multinucleate) -> myofibrils
What is significant about muscle fibers?
Large and multinucleate
What are muscle fibers bundled by?
Connective tissue
What are myofibrils?
highly organized assemblages of myosin and actin filaments
What is one muscle fiber made of?
Many myofibrils
What are the contractile proteins in skeletal muscles?
Actin and myosin
What is actin?
A contractile protein, thin filament
What is myosin?
A contractile protein, thick filament
How are actin and myosin arranged?
Lie in parallel and slide past each other during contraction
What do actin and myosin form?
Sarcomeres
What do actin and myosin form?
Sarcomeres
What do multiple sarcomeres form?
A single myofibril
What is the Z line?
Where actin is connected
What is the M band?
The middle, myosin is attached here
What is titin?
A protein that runs from Z line to Z line
What is the A band?
from myosin to myosin
What is the H zone?
only myosin
What is the I band?
only actin
What happens to actin and myosin during muscle contraction?
They slide against each other
Who founded the muscle contraction model?
Hugh Huxley and Andrew Huxley simultaneously discovered the model in Cambridge; did not know each other
What happens to a sarcomere when a muscle contracts?
It gets smaller
What happens to a sarcomere when a muscle relaxes?
It gets larger
What happens to a sarcomere when a muscle relaxes?
It gets larger
Which lines stay the same when a muscle contracts or relaxes?
M band, A band
Which lines get smaller when a muscle contracts or relaxes?
Z to Z, I band, H zone
Which lines get smaller when a muscle contracts or relaxes?
Z to Z, I band, H zone
What does sarcomere length determine?
Force
What determines force of a muscle?
Sarcomere length
What happens when actin and myosin are fully contracted?
No more space for shortening
What happens when actin and myosin are fully stretched?
Less force, hard to pass each other
What happens when actin and myosin are fully stretched?
Less force, hard to pass each other
How does the peripheral nervous system send things to the CNS?
Afferent/sensory neurons
How does the CNS send things to the peripheral nervous system?
Effector/motor neurons which can be voluntary (skeletal muscle) and autonomic/involuntary (cardiac, smooth muscle)
How does the CNS send things to the peripheral nervous system?
Effector/motor neurons which can be voluntary (skeletal muscle) and autonomic/involuntary (cardiac, smooth muscle)
What is autonomic?
Involuntary
Where does skeletal muscle contraction start?
At the motor neuron
Where does skeletal muscle contraction start?
At the motor neuron
What is the process of skeletal muscle contraction?
Motor neuron makes contact with muscle cell (neuromuscular junction) –> AP arrives from motor neuron spread across muscle fiber membrane –> travels inside cell to reach myofibrils –> Actin and myosin can contract/pass each other in response to signals
What is the process of skeletal muscle contraction?
Motor neuron makes contact with muscle cell (neuromuscular junction) –> AP arrives from motor neuron spread across muscle fiber membrane –> travels inside cell to reach myofibrils –> Actin and myosin can contract/pass each other in response to signals
What is a motor unit?
One motor neuron and all the muscle fibers it synapses with
What is the presynaptic cell?
Motor neuron
What is the neuromuscular junction?
Junction between motor neuron and muscle cell membrane
What are the neurotransmitters in muscle contraction?
Acetylcholine
What are acetylcholine molecules?
Neurotransmitters in muscle contraction
Where are acetylcholine molecules in muscle contraction?
In vesicles in the motor neuron
What does the axon terminal do?
Releases acetylcholine
What does the axon terminal do?
Releases acetylcholine
What does acetylcholine do once released from the axon terminal?
Binds to receptors on the muscle cells
What happens when acetylcholine binds to receptors on the muscle cells?
Na+ enters the muscle cells, changing membrane potential and triggering more Na+ ion channels to open –> AP
What is the postsynaptic cell?
Motor end plate of muscle cell
What is the postsynaptic cell?
Motor end plate of muscle cell
What spreads the AP into the muscle fiber?
T Tubules, sarcoplasmic reticulum
What is sarcoplasmic reticulum?
Membrane-like structure that helps spread AP in muscle fiber; stores Ca2+ (Calcium pump on the membrane of the reticulum keeps sucking Ca2+ into the reticulum)
What does the AP in T Tubules affect?
DHP and ryanodine receptors on the sarcoplasmic reticulum
What is sarcoplasmic reticulum?
Membrane-like structure that helps spread AP in muscle fiber; stores Ca2+ (Calcium pump on the membrane of the reticulum keeps sucking Ca2+ into the reticulum–leak channel?)
What does the AP in T Tubules affect?
DHP and ryanodine receptors on the sarcoplasmic reticulum
What happens once the DHP and ryanodine receptors are affected on the sarcoplasmic reticulum?
The proteins change shape and no longer connect, thus causing Ca2+ to be released from the reticulum to the outside, spreading eventually to actin and myosin.
What happens once the DHP and ryanodine receptors are affected on the sarcoplasmic reticulum?
The proteins change shape and no longer connect, thus causing Ca2+ to be released from the reticulum to the outside, spreading eventually to actin and myosin.
What does the sarcoplasmic reticulum release Ca2+ into?
The sarcoplasm (muscle fiber cytoplasm)
What does the sarcoplasmic reticulum release Ca2+ into?
The sarcoplasm (muscle fiber cytoplasm)
What receptors are in the sarcoplasmic reticulum?
DHP and ryanodine receptors
What does a Ca2+ increase in the sarcoplasm initiate?
Myofibril to contract
What does myofibril contraction depend on?
Structures of actin and myosin filaments
What is actin made of?
The actin monomer, tropomyosin, and troponin
What does myofibril contraction depend on for skeletal muscle?
Structures of actin and myosin filaments
What is actin made of?
Proteins: actin monomer, tropomyosin, and troponin
What is the actin monomer?
The bead structure
2 together forms an actin polymer
What is tropomyosin?
A protein that is a long strand, covers certain points on actin (the orange dots that are the myosin-binding sites)
What is troponin?
a protein that has 3 subunits: 1 binds to tropomyosin, 1 binds to actin, and 1 that’s a linker