Lecture 36- Escheria & Klebsiella

Question 1

Describe Eschericha coli etiology

Answer 1

coliform
enteric- grows in GI tract
stool tool (helps to identify presence of feces)
ENTEROTOXIGENIC (ETEC E. coli)
2 toxins that cause a lot of water to be ejected with feces- LT (heat labile) and ST (heat stabile)
ENTEROINVASIVE
produce shigella by conjugation
affects large intestine
ENTEROPATHOGENIC/ENTEROHEMMHORAGIC 
produce shiga toxin by conjugation
E coli O157:H7 causes severe diarrhea

Question 2

What infections does E. coli cause? (5)

Answer 2

cystitis (uncomplicated)- UTI that involves bladder
epidemic diarrhea- enteropathogenic strains such as O157:H7. aka summer or infantile diarrhea
Traveler’s diarrhea- uncooked food. Enterotoxigenic strains
Peritonis- feces gets into peritoneum (lining of the body cavity)
appendicitis

Question 3

How do you diagnose and treat E. coli?

Answer 3

serological tests
if strain is unknown use bactrim (sulfamethoxizole and trimethoprim)
if strain is known use cephempine, ceftriaxone or cefotaxime

Question 4

Describe klebsiella

Answer 4

klebsiella pneumoniae
coliform
enteric
stool tool (helps to identify presence of feces)
large capsule
accounts for 10% of nosocomial pneumonia (intubation, septicemia in pediatric wards)
DOC is cephalosporins such as ceftriaxone, cefotaximeme, or cepempine