Lecture 32 Flashcards
Introduction to Nutrition
diets
- all diets have some evidence base
- all diets can be criticized
- the best healthy diet is the one you will be compliant to
pg 747
Why is there public mistruct in nutritional science (dietary guidelines)?
nutritional quackery -> what the media puts out about nutrition
pg 749
nutrition
- systems biology
- no person consumes each nutrient separately
- nutrients work together
- nutrients are recycled
- nutrients do not target one organ/tissue or metabolic pathway
- nutrients are multifunctional
pg 754
hypothesis: plant based diet can help to mediate inflammation which may reduce the pain response
nutrition and its study is inherently more complicated compared to drugs
- drug trials (aspiring): have a primary variable of pain, secondary variable of quality of life, and an established mechanism exists
- nutritional trial: primary varible of pain, secondary variable of quality of life, mechanism???
pg 755
RCT’s and nutrition
- RCTs designed to be better for drugs, hard to use for nutrition
- can’t really have a placebo/control group because you can’t find people who have never had nutrition
- nutrients are absolutely required daily for all people
- nutrients have no one particular outcome
- better to use dose-response studies
pg 756
food is medicine
- recognizes that nourishment is essential for good health, wellbeing, and resilience
- nourishment is essential to more than physical health -> foster mental, social, and behavioral benefits -> is important across the life course in every setting
pg 759
diet/nutrition and hippocratic oath or osteopathic oath
- original hippocratic oath: “I will use those dietary regimens which will benefit my patients accordig to my greatest ability and judgement”
- modern hippocratic oath does NOT mention anything about nutrition
- osteopathic oath: “I will be ever alert to further the application of basic biologic truths to the healing arts” -> nutrition is a basic biologic truth
pg 761-762
six classes of nutrients
- carbohydrate
- protein -> biological value
- lipids -> SFA, MUFA, PUFA, cholesterol, phospholipids
- water -> hydration is one of the most important nutrients
- vitamins -> water soluble, fat soluble
- minerals -> macrominerals, microminerals, ultra trace minerals, electrolytes
Categories:
- macronutrients: carbs, protein, lipids, water
- micronutrients: vitamins, minerals
- organic (carbon containing): carbs, protein, lipids, vitamins
- inorganic: minerals, water
- energy yielding: carbs, protein, lipids
pg 764-765
calories for nutrient classes
- carbohydrates: 4 kcal/g (some sweeteners and some fibers 2 kcal/g)
- proteins: 4 kcal/g
- fat: 9 kcal/g
- alcohol: 7 kcal/g
pg 765
dietary reference intakes (DRI)
- set of standards in US and Canada
- recommended intakes of energy, nutrients, other dietary components to support health in relatively healthy people
- can be used to plan and evaluate dietary intakes for healthy people
- determined based on sex and age
pg 766
estimate average requirement (EAR)
average daily nutrient intake level estimated to meet the requirement of half the healthy individuals in a particular age, sex, and life-stage group
pg 767
recommended dietary allowance (RDA)
average daily nutrient intake level sufficient to meet the nutrient requirement of nearly all (97-98%) healthy individuals in a particular age, sex, and life-stage group (2 SDs from the EAR)
pg 767
adequate intake (AI)
an intake (not a requirement) that is likely to exceed the actual requirements of almost all individuals in an age, sex, and life-stage group; established when scientific evidence is not sufficient to determine an RDA
pg 767
tolerable upper intake level (UL)
the highest average daily nutrient intake level likely to pose no risk of adverse health effects for nearly all people in a particular age, sex, and life-stage group (toxicity cutoff)
pg 767
chronic disease risk reduction intake (CDRR)
nutrient intake level expected to reduce the risk of developing chronic disease within an apparent healthy population, will be set once evidence level is at least moderate strength of evidence for both a causal and an intake-response relationship between nutrient intake and chronic disease risk
pg 767