Lecture 3: specific immunity Flashcards
1
Q
What cytokine induces myeloid cell differentiation?
A.IL-3
B.IL-7
C. IL-8
D. IL-2
E. IL-4
A
A. IL-3
2
Q
What cytokine induces lymphoid cell differentiation?
A.IL-3
B.IL-7
C. IL-8
D. IL-2
E. IL-4
A
B. IL-7
3
Q
- MHC I
- TCR- it binds antigen-MHC complexes
- CD3- it’s associated w/ TCR for signal transduction
- CD28- it binds B7 on APCs (dendritic cells)
- CD4
- CD40 ligand
A
Cell surface markers on Th cells
4
Q
- MHC I
- TCR- it binds antigen-MHC complexes
- CD3- it’s associated w/ TCR for signal transduction
- CD28- it binds B7 on APCs (dendritic cells)
- CD8
A
Cell surface markers on cytotoxic T cells
5
Q
- MHC II-presents to effector T cells in secondary immune response
- Ig (binds antigen)
- CD19-signal transduction
- CD20-signal transduction
- CD21-signal transduction, binds EBV
- CD40- interacts w/ CD40L on Th cells
- B7-1 (CD80) and B7-2 (CD81)- bind CD28 and CTLA-4
- CD10- it’s present on pre- _cells, usually as a marker (diagnostic) for malignant transformation states- leukemias and lymphomas
- FCgama R CD32- binds FC region of IgG when aggregated or bound antigen
A
Cell surface markers on B cells
6
Q
- MHC II
- B7
- CD14
- CD40
- Fc receptor (enhances phagocytosis)
- C3b receptor (enhances phagocytosis)
A
Cell surface markers expressed by macrophages
7
Q
- CD 16 (binds Fc of IgG)
- CD 56
A
Cell surface markers expressed by NK cells
8
Q
- they’re APCs
- they’re the best APCs for T-cells (except for follicular dendritic cells), b/c they constitutively express B7.
- follicular dendritic cells activate memory B cells to generate secondary antibody response
- They’re BM (bone marrow) derived
- They can endocytize antigen but NOT kill it
- they generate immune response in naive individuals (naive=never exposed to antigen)
A
dendritic cells
