Lecture 3: Management of Common Fluid Imbalances Flashcards
what % of adult body weight is water
60
what are the 2 body fluid compartments
- extracellular
- intracellular
what is extracellular fluid (ECF)
- 1/3 of body water
1. Intravascular: plasma (5%) (liquid portion of blood) - btwn cells: interstitial (15%) and lymph (immune system fluid)
2. Transcellular fluid (CSF, GI tract, pleural spaces, synovial spaces, peritoneal spaces)
intracellular fluid (ICF)
- 2/3 of body water
- located within cells
(40% of body weight)
calculation of fluid gain/loss
1 L of H20 weighs 1 Kg
body weight change is a great indicator of fluid loss (ex: daily weights)
if a pt is on a diuretic loses 2kg in 24 hrs they have lost approx 2 L of fluid
what are electrolytes
- molecules dissociate into ions when in water
- cations: positively charged (Na+,K+,Ca2+, Mg2+)
- anions: -‘ve charge (bicarbonate, Cl-, phosphate)
measurement of electrolytes
mmol/L
mech for controlling fluid and electrolyte movement
- diffusion
- facilitated diffusion
- active transport
- osmosis
- hydrostatic pressure
- oncotic pressure
what is diffusion
movement of molecules from high to low concentration
- membrane separating the 2 areas must be permeable to diffusing substances
- no ATP
facilitated diffusion
- movement of molecules from high to low concentration
- no ATP
- uses specific carrier molecules to accelerate diffusion
- glucose transport into the cell
active transport
- process in which molecules move against concentration gradient (ex: Na-K pump)
- external energy required
osmosis
- movement of h2o btwn 2 compartments by membrane permeable to h2o but not solute
- moves from low to high solute
- no ATP
osmotic pressure
amount of pressure required to stop osmotic flow of water
- determined by concentration of solutes in solution
osmolality
concentration of molecules per weight of water
plasma (liquid portion in blood) osmolality is 280-300 mmol/kg
oncotic pressure
(colloidal osmotic pressure)
- osmotic pressure exerted by colloids in solution
major collioid in vascular sys contributing to total osmotic pressure is albumin
albumin
- protein made by liver
- keeps fluid in vascular space
- albumin is low, fluid leaks out of vascular space
fluids with the same osmolality as the cell interior are ->
ISOTONIC, normally the ECF and ICF are isotonic to one another
fluids in which solutes are less concentrated than they are in cells are
HYPOTONIC (goes in)
fluids in which the solutes are more concentrated than they are in the cells are
HYPERTONIC (goes out)
hydrostatic pressure
- force within fluid compartment
- major force that pushes water out of vascular sys at capillary level