L14: Arthritis Flashcards

1
Q

what is arthritis

A
  • inflammation of joints or singular joint
  • most common: osteoarthritis
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2
Q

is there a treatment for osteoarthritis

A

nope

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3
Q

what is osteoporosis

A
  • aging is a risk factor
  • NOT part of normal aging process
  • cartilage destruction can begin between ages 20-30
  • few pt experience sympt until after age 50-60
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4
Q

2 categories of arthritis

A
  1. idiopathic disorder
  2. secondary disorder
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5
Q

what does OA result in

A
  • cartilage damage that triggers a metabolic response
  • cartilage erodes at articular surfaces of joint
  • bone spurs (osteophytes) may form
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6
Q

in OA what does cartilage become

A
  • dull, yellow, and granular
  • soft and less elastic
  • less able to resist wear w heavy use
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7
Q

what is NOT a characteristic of OA

A

secondary synovitis may result

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8
Q

3 stages of OA manifestation

A

stage 1: predictable, sharp
stage 2: more constant, affecting daily activities
stage 3: constant dull/aching pain

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9
Q

crepitation

A

grating sensation due to loose particles of cartilage

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10
Q

does OA affect the joints asymmetrically or symmetrically

A

asymmetrically

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11
Q

what is the main restriction of OA

A

mobility restriction

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12
Q

heberden’s nodes

A

DIP joints
- osteophyte formation and loss of joint space
- can appear as early as 40 yrs

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13
Q

bouchard’s nodes

A

PIP joints
- similar disease involvement as heberden’s nodes

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14
Q

bow-leggedness

A

medial knee joint
- joint deformity

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15
Q

knocked-kneed

A

lateral knee joint
- joint deformity

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16
Q

diagnostic studies of OA

A
  • bone scan, MRI, CT (detect early joint changes)
  • x-ray
  • inflammatory markers (erythrocyte sedimentation)
  • synovial fluid analysis
17
Q

clinical diagnosis of OA

A
  • persistent joint pain for 1 or more joints
  • age greater or equal to 45 yrs
  • morning stiffness less than or equal to 30 min
18
Q

collaborative care of OA

A
  • no cure
  • non-pharmacological interventions
  • pt education and self-management
  • drug therapy is considered adjunct therapy
  • reconstructive surgery
19
Q

drug therapy for OA

A
  • NSAIDS (oral and topical): PPI’s, topical: one or a few joints only, oral: celebrex
  • capsaicin cream (1 or few joints involved)
  • tylenol (not more than 4g/day)
  • duloxetine (multiple joints)
  • corticosteroids (intra-articular injections of corticosteroids)
  • hyaluronic acid injection
  • doxycycline (decreased joint deterioration **investigational)
20
Q

rheumatoid arthritis

A

chronic, systemic autoimmune disease characterized by inflammation of connective tissue in the diarthrodial (synovial) joints, typically w periods of remission and exacerbation

  • early recognition and treatment are key
21
Q

rheumatoid arthritis etiology

A

is unknown: possible autoimmune, enviro triggers genetic endowment, genetic factors, antigen triggers to form abnormal immunoglobulin G

22
Q

how is RA characterized

A
  • by the presence of autoantibodies against abnormal IgG - known as rheumatoid factor
23
Q

does RA occur asymmetrically or symmetrically

A

symmetrically: affects small joints of hand and feet (PIP and MTP joints)

24
Q

extra-articular manifestations of RA

A
  • flexion contractors and deformity
  • rheumatoid nodules
  • sjögren’s syndrome
  • felty’s syndrome
25
Q

is OA more commonly idiopathic or secondary

A

idiopathic

26
Q

what is sjögren’s syndrome in RA

A
  • extra-articular manifestations
  • decreases lacrimal and salivary gland secretion
27
Q

what is felty’s syndrome in RA

A
  • extra-articular manifestations
  • splenomegaly, decreased WBCs
  • increased risk for infection and lymphoma
28
Q

complications of RA

A
  • joint destruction begins as early as 1st yr w/o treatment
  • flexion contractures and hand deformities
  • cataracts and loss of vision
  • later in the disease…cardiopulmonary
29
Q

RA diagnostics

A
  • history and physical
  • positive RF: titers rise during active disease
  • synovial fluid analysis: straw colored w fibrin flecks, increased WBC
  • x-ray: baseline and monitoring of joint spaces (not specifically diagnostic)
  • bone scan: can confirm a dx by detecting early joint changes
30
Q

RA diagnostic criteria

A
  • inflammatory arthritis involving 1+ joints
  • +’ve rheumatoid factors and anti-CCP
  • elevated levels of C-reactive protein (CRP) or the erythrocyte sedimentation rate (ESR)
  • diseases w similar clinical features have been excluded
  • duration of sympt is 6+ weeks
31
Q

drug therapy for RA

A
  • DMARDs (disease modifying antirheumatic drugs): methotrexate 1st choice!
  • corticosteroids, NSAIDS for sympt management
32
Q

OA
age of onset:
weight:
disease:
affected joints:
pain:
labs:

A

age of onset: usually over 40yrs
weight: usually overweight
disease: localized
affected joints: weight-bearing joints, asymmetrical
pain: subsides after 30 min of rising
labs: RF -‘ve; transient elevation of ESR in synovitis

33
Q

RA
age of onset:
weight:
disease:
affected joints:
pain:
labs:

A

age of onset: young to middle age (mostly women), may have a genetic component
weight: lost or maintained weight
disease: systemic-fever, fatigue
affected joints: small joints 1st, usually bilateral and symmetrical
pain: pain lasts 1 hr to all day; variable
labs: RF +’ve in 80% of clients, anti-CCP; elevated ESR & CRP

34
Q

what is the difference in bone impact btwn OA vs RA

A

OA: bone ends rub together
RA: swollen, inflamed synovial membrane