Lecture 3 and 4- cell signaling

Question 1

4 types of signaling receptors

Answer 1

1. ligand-activated ion channels
2. G protein coupled receptors
3. tyrosine kinase receptors
4. ligand activated transcription factors

Question 2

about …% of drugs are directed agonists or antagonists of one or anoter G protein coupled receptor

Answer 2

40

Question 3

Ligand-activated ion channels:

what are 4 ways that drugs can affect synaptic transmission ?

Answer 3

1. mimic or block actions of neurotransmitters
2. block the channel
3. interfere with neurotransmitter reuptake
4. interefere with neurotransmitter metabolism

Question 4

agonists bind to GPCR’s, alter the protein’s conformation, leading to activation of a …

Answer 4

trimeric G protein

Question 5

arachidonic acid is the source of …. signaling molecules

Answer 5

eicosinoid

Question 6

arachidonic acid is he source of …. which are important signaling molecules and mediators of pain and inflammation

Answer 6

prostaglandins

Question 7

cleavage of … by phospholipase C yields DAG and IP3

Answer 7

PIP2

Question 8

endocytosed receptor has 2 possible fates

Answer 8

1. recycling

2. degradation