Lecture 1- pharmacological receptors Flashcards
the majority of drugs fxn by interacting with …. and either facilitatin (agonist) or blocking (antagonist) their fxn
receptor proteins
pilocarpine and atropine produce their effects by acting upon ….. receptor proteins of salivary glands
muscarinic acetylcholine
muscarinic …. can produce xerostomia
antagonists
atropine is a muscarinic …
antagonist
pilocarpine is a muscarinic …
agonist
curare blocks
nicotine
interaction of a drug with a receptor is based on the law of …
mass action
equation for the dissociation constant
R*L/ RL = Kd
what does the plot look like of drug bound to receptor vs. drug concentration
rectangular hyperbola
as Lf approaches infinity, RL/Rt approaches…
which means that once the drug concentration is high enough basically all of the receptor will …
1
contain bound drug
the equilibrium or dissociation constant describes the drug concentration required for …
1/2 maximal binding to the receptor
is it possible that two drugs act at the same receptor site but require vastly different concentrations to achieve the same effect?
yes
the amount of drug bound to the receptor would depend on both the ….. available for binding as well as the ….
concentration of the drug
dissociation constant (Kd)
if a drug has a higher Kd then will more or less drug be required to chieve the binding equivalent of a drug with a lower Kd?
more
T/F: If X amount of drug produces a certain effect, 2X amount of a drug will produce roughly 2X as much of an effect
FALSE. depends where you are on binding curve.
if amount of drug bound is low then doubling will have a large effect.
if amount of drug bound is high then doubling will have a small effect
