Lecture 3 Flashcards
What factors are crucial for a drug’s therapeutic activity?
Solubility and bioavailability.
What is the purpose of nicotine replacement therapy (NRT)?
To deliver nicotine to the body and help people quit smoking.
Name some OTC forms of NRT.
Patches, gum, lozenges
What are some unit processes involved in the production of dosage forms
Weighing, milling, mixing, granulation, drying, compacting, coating, and packaging
What are the benefits of proper mixing in drug formulation?
Uniform distribution of the API, consistent appearance, and correct API release site and rate
How are excipients classified?
Into those aiding manufacturing and those enhancing the final product’s physical characteristics.
What are the three types of mixtures in drug manufacturing?
Neutral mixtures, positive mixtures, and negative mixtures.
What type of mix is most common in practice?
A random mix, where particles are distributed randomly.
What are three mechanisms of mixing?
Convection mixing, diffusion mixing, and shear mixing.
What is the purpose of milling in pharmaceuticals?
To reduce particle size for better dissolution, therapeutic efficiency, and product texture
Name three common types of mills used in the pharmaceutical industry.
Rotary cutter mills, hammer roller mills, and fluid energy mills (micronisers).
What factors influence the milling process?
Presence of water, heat, and the material’s physical and chemical properties.
What is drying in pharmaceutical production?
The removal of liquid from material by applying heat.
Name some types of dryers used in pharmaceuticals.
Tray dryers, tunnel dryers, and rotary dryers.
What is freeze drying, and when is it used
A method for drying heat-sensitive products at low temperatures, used for biopharmaceuticals like vaccines and proteins.
