Lecture 2.6

Question 1

Which two organ systems require HLA matching

Answer 1

Kidney, Bone marrow

Question 2

Which tow organ systems do not require HLA matching and thus use size, gender, and blood group to match

Answer 2

Heart and lung

Question 3

The sum of allo MHC and non-self peptide from the donor results in what from the recipient?

Answer 3

Stimulation of T-cells

Question 4

What are the two pathways of rejection?

Answer 4

Indirect and direct

Question 5

In direct pathway of rejection, where does the APC come from (donor/recipient)

Answer 5

Donor

Question 6

Which pathway of rejection can stimulate CD4 and CD8 cells at the same time?

Answer 6

Direct pathway

Question 7

In this pathways, most donor peptide (coming from donor MHC) is presented in the context Class II MHC antigens with recipient APC

Answer 7

Indirect pathway

Question 8

Of the two rejection pathways, which one is considered acute and which one is considered chronic?

Answer 8

Direct, acute/ indirect,chronic

Question 9

This timing rejection happen minutes to hours after the graft is placed and usually is identified by thrombosis

Answer 9

Hyperacute, preexisting antibodies bind to endothelial cells of donor and then activate the complement and coagulating cascade–> neutrophils invade and cause inflammation and thrombosis

Question 10

Happens 8-10 days after transplantation, CD8 cells kill graft cell directly, CD4 cells trigger delayed hypersensitivity

Answer 10

Acute rejection

Question 11

Rejection characterized by obliterative lesion, happens after months to years, and may be the results of intimal smooth muscle proliferation and vessel occlusion

Answer 11

Chronic rejection

Question 12

What are the two approaches to stopping rejection?

Answer 12

Proximal (before recipient T-cell recognition), distal (after recipient T-cell recognition)