Lecture 2.2

Question 1

Type of hypersensitivity that is know as allergic reactions

Answer 1

Type 1, immediate hypersensitivity

Question 2

Type 1 hypersensitivity is a results of what type of antibody binding to what type of cell?

Answer 2

IgE binding to mast cells

Question 3

What are three types of actions that occur as a result of Type 1 hypersensitivity?

Answer 3

1. Vascular dilation, vascular permeability
2. Smooth muscle contraction
3. Cellular infiltration

Question 4

Food allergies, bronchial asthma, allergic rhinitis are examples of this type of hypersensitivity

Answer 4

Immediate

Question 5

Pemphigus vulgarius, goodpasture’s syndrome, Myasthenia gravis, graves disease are examples of this type of hypersensitivity

Answer 5

Type 2, antibody mediated hypersensitivity

Question 6

Antibodies form to the cell-cell adhesion junctions between keratinocytes and binding to the antigens leads to fluid filled vesicles and bullae in this disease

Answer 6

Pemphigus vulgarius

Question 7

Antibodies bind to type 4 collagen of the basement membrane in the kidneys and lung and results in the activation of complement and release of tissue damaging enzymes in disease

Answer 7

Goodpasture’s syndrome

Question 8

This type of hypersensitivity involves the depositing of complexes in blood vessels leading to complement activation and inflammation, diseases include Lupus erythematosus, polyarithemia nodusa, poststrep glomerunephritis, serum sickness, andrus reaction

Answer 8

Type 3, Immune Complex disease

Question 9

Inflammatory bowel disease and contact dermatitis are part of this type of hypersensitivity

Answer 9

Type 4, T-cell mediated, also known as delayed hypersensitivity