Lecture 25 Flashcards
1
Q
Common causes of cell injury
A
Metabolic: oxygen deprivation, nutritional Chemical Physical Biological Immunological Genetic Aging
2
Q
Intracellular systms affected by injury
A
Cell membrane integrity
ATP production
Protein synthesis
Genomic or chromosomal integrity
3
Q
Early cellular responses to injury
A
Cloudy swelling
Hydropic degeneration: stain faintly
Fatty change: accumulate ACG
4
Q
Cellular adaptations to nonlethal injury
A
Atrophy
Hypertrophy
Hyperplasia
Metaplasia
5
Q
Hypertrophy
A
Reversible
Cardiac muscle, skeletal muscle, uterus
6
Q
Hyperplasia
A
Endometrium Prostate gland RBC Glandular epithelium of breast Uterine enlargement
7
Q
Atrophy
A
Testis in elderly
Skeletal muscle
Brain
8
Q
Metaplasia
A
Respiratory epithelium
Cervical epithelium
Esophageal epithelium
9
Q
Dysplasia
A
Cervix, skin High nuclei to cytoplasm ratio Large nuclei with darkly staind chromatin May lead to neoplasia Borderline to reversibility
10
Q
Neoplasia
A
Irreversible
Benign or malignant
