Clinical Pharmacokinetics 2 Flashcards

1
Q

Maintenance doses

A

To maintain the plasma concentration within a specified range over long periods of therapy

At SS, dosing rate = elimination rate = CL*C/F

If intermittent doses: maintenance dose = dosing rate * dosing interval

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2
Q

Loading dose

A

Achieve a target plasma level rapidly

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3
Q

The dosing plan is base on

A

Therapeutic window
CL
Vd

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4
Q

Continuous IV infusion

A

Rate of elimination = CL * C

Css = infusion rate/CL

Loading dose = Vd*TC/F

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5
Q

Single IV injection

A

C will peak and decreae exponentially

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6
Q

Multiple IV injection

A

C increases until SS is achieved
C fluctuates about a mean

Given smaller doses at a shorter intervals reduces the amplitude of the swings in C

Css and the rate at which SS is approached are not affected by dosing frequency

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7
Q

Orally administered drugs

Single

A

Yields a more round peak

Changing the rate of absorption: rapid release vs. slow release

Slow release: delayed & lower peak, higher levels at later time > less frequent administration of drugs with short half-lives, prolong effects

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8
Q

Orally administered drugs

Multiple

A

The oscillations in C are influenced by both rate of absorption and rate of elimination

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