Connective Tissue Lecture Flashcards
Parenchyma
Functional cellular units
Stroma
CT
Supporting structures
Embryonic connective tissue 2
Mesenchyme
Mucous CT
CT proper
Loose CT
Dense CT
-regular = DRCT
-irregular = DICT
Specialized CT
Cartilage Bone Blood & hematopoietic tissue Adipose tissue Elastic tissue Reticular tissue
Components of ECM
Fiber
Ground substance
Tissue fluid
4 functions of ground substance
Glue
Lubricant
Barrier
Tensile strength
Types of collage and location
Type I: most abundant
Type II: cartilage
Type III: reticular
Type IV: BM
Composition of mucous CT
Jelly like
Few cells or fibers
Abundant ground substance
Location of mucous CT 3
Umbilical cord = Wharton’s jelly
Cardiac jelly
Vitreous humor in eye
Components of LCT = areolar
Abundant cells of various type
Few fiber
Abundant GS
Function and location of LCT
Flexible, not resistant to stress, rich in blood supply
Loosely thin and sparse collagen fibers
Beneath epithelium
Surrounds glands and smallest BV
Location of lamina propria
LCT of mucosa
Lining:
Respiratory tract
GI tract
Urogenital tract
Components of DICT
Few cells of single type, fibroblast
Abundant fiber, mostly collagen
Little GS
Collagen fibers have no orientation - resistant to stress in all directions
Significant strength
Banding pattern of collagen fiber
68 nm
Collagen fibrils often consist of more than one type of collagen
Components of DRCT
Abundant fiber, mostly collagen fibers, in a specific orientation
Few cells of single type, fibroblast, have processes
Little GS
Place of DRCT
Tendons/ligaments
Tendinocyte
Fibroblast in tendon
More thin processes
More cytoplasm
In tendon, differentiate epitendineum, peritendineum, endotendineum
Epitendineum: covering an entiry tendon
Peritendineum: covering around a group of fascicles
Endotendineum: CT covering around a group of fibers
Levels of tendon
Collagen fibril > collagen fiber > promary fiber bundle = subfascicle > secondary fiber bundle fascicle > tertiary fiber bundle > tendon
Reticular CT
Reticular cells = modidied fibroblasts
Framework for myeloid (bone marrow) and lymphoid organs (lymph nodes, spleen)
Collagen III fiber
Elastic CT
Central core of elastic surrounded by fibrillin microfibrils
Produced by fibroblasts and smooth muscle cells
Stain: orcein,resorcin, or Verhoeff’s
Location of elastic CT
Elastic arteries, elastic cartilage, vocal ligament, suspensory ligament of the penis
Cartilage cells
Chondroblasts/ chondrocytes
Bone cells
Osteoblasts
Osteoclasts
Osteocytes
Blood cells
Erythrocytes
Leukocytes
Hypertrophic scar
Raised than normal, but within original wound boundary
Caused by increased collagen production
Keloid scar
In excess of the boundary, extending into surrounding tissue
Caused by increased collagen production
Anaphylactic shock
Increased mast cell release of histamine
Allergy
Edema
Increased tissue fluid
Water in bv flows into CT