lecture 23 Flashcards
describe spontaneous mutations - strand slippage during replication
a
describe spontaneous mutations - strand slippage during replication - insertion
a
describe spontaneous mutations - strand slippage during replication - deletion
a
what is cause of many trinucleotide repeat diseases
a
describe example: trinucleotide repeat expansion in non-coding region of the FMR1 gene causes Fragile X Syndrome
a
Example: trinucleotide repeat expansion in coding region of the HTT gene causes huntingtons disease
a
what can spontaneous mutations be caused by
a
give ex of spontaneous chemical change to dna - deamination
a
give ex of spontaneous chemical change to dna - depurination
h
what can lead to permanent dna mutations
a
describe molecular basis of induced mutations
a
name the 3 mechanisms by which mutagens can induce mutations
a
describe some exs of mutagens and their effects - gen
a
describe molecular basis of induced mutations - base damage uv light
a
describe molecular basis of induced mutations - base damage ionizing radiation
a
How do we know if something is a mutagen?
a
explain rational behind ames test
a
problem with ames test
a
Describe ames test for mutagenic compounds - revised
a
Why did the revised Ames test include these two different Salmonella strains?
a
describe interpretation for ames test for mutagenic compounds
a
how can we read and understand a genome
a
