lecture 22 Flashcards

1
Q

what are mutations

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2
Q

where do most mutations occur

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3
Q

what types of mutations can be passed on

A

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4
Q

describe inherited mutations

A

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5
Q

Why will only half of the F1 individuals carry the mutation?

A

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6
Q

what is a mutation

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7
Q

what can mutations be

A

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8
Q

Explain how mutations can be a source of genetic variation

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9
Q

name the 3 types of scales of mutations

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10
Q

describe chromosomal mutation

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11
Q

describe insertional mutation

A

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12
Q

describe point mutation

A

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13
Q

name categories of point mutations - 2

A

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14
Q

describe base sub point mutations

A

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15
Q

describe the consequences of point mutations in open reading frames - synonymous mutations

A

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16
Q

describe the consequences of point mutations in open reading frames - nonsynonymous mutations

17
Q

describe the consequences of point mutations in open reading frames - nonsense mutations

18
Q

describe the consequences of point mutations in open reading frames - frameshift mutations

19
Q

describe what happens when single base sub

20
Q

describe what happens when single base insertion or deletion

21
Q

do all point mutations have same effect and explain

22
Q

describe wild type function

23
Q

describe loss of function

24
Q

describe gain of function

25
give ex of loss of function
a
26
give ex of gain of function
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27
can sequences in non coding regions be important for gene function?
a
28
describe consequences of point mutations in non-coding regions
a
29
Why do some patients with a mutation in the PBRM1 gene have a worse prognosis?
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30
describe ex of BAP1
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31
describe Effect of point mutations on a gene’s mRNA and protein products
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32
describe consequences of point mutations within genes
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33
can mutations be spontaneous or induced
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34
describe origins of spontaneous mutations
a
35
describe origins of spontaneous mutations - errors in base pairing
a