Lecture 2.10 Viruses Flashcards
What are the features of rotavirus?
Causes diarrhoea in kids under 5, vaccine not widely used, need rehydration, virus has multiple capsid shells to protect it moving through the GIT
What are the features of HIV/AIDS?
Virus grows in immune cells and chips away at CD4T cells - immunodeficiency. Reduction in deaths due to combined antiviral treatment, 70% go global AIDS population (25.8 mil) in sub saharan africa, only 54% of people with AIDS know they have it
What are the features of viruses?
Floating around - have to invade host cell to replicate, have a capsid shell for protection and sometimes an envelope surrounding that (formed by host cell membrane) and a matrix - connects the envelope and capsid glycoproteins. Virus can be +ve sense (mRNA) or -ve sense (complementary strand)
What is capsid symmetry, the types, and the viruses?
Capsid symmetry protects the viral genome from nucleosomes breaking it down
- Icosahedral: adenovirus, herpes, pailloma
- Helical: influenza, mumps
What is poxvirus?
Largest virus, has 130kbp and can form >100 proteins
What are arboviruses?
Infect insects that ingest vertebrae blood, replicate in insect and transmitted by bite
What does hepatitis target and how do the types move through the body?
Targets the liver
A & E - enteric
B, C & D - via blood or sex
What are the features of SARS?
Severe acute respiratory syndrome, pneumonia, small epidemic pop but fast spreading, controlled by public health measures, grew in cultured vero cells