Lecture 2.10 Viruses

Question 1

What are the features of rotavirus?

Answer 1

Causes diarrhoea in kids under 5, vaccine not widely used, need rehydration, virus has multiple capsid shells to protect it moving through the GIT

Question 2

What are the features of HIV/AIDS?

Answer 2

Virus grows in immune cells and chips away at CD4T cells - immunodeficiency. Reduction in deaths due to combined antiviral treatment, 70% go global AIDS population (25.8 mil) in sub saharan africa, only 54% of people with AIDS know they have it

Question 3

What are the features of viruses?

Answer 3

Floating around - have to invade host cell to replicate, have a capsid shell for protection and sometimes an envelope surrounding that (formed by host cell membrane) and a matrix - connects the envelope and capsid glycoproteins. Virus can be +ve sense (mRNA) or -ve sense (complementary strand)

Question 4

What is capsid symmetry, the types, and the viruses?

Answer 4

Capsid symmetry protects the viral genome from nucleosomes breaking it down

• Icosahedral: adenovirus, herpes, pailloma
• Helical: influenza, mumps

Question 5

What is poxvirus?

Answer 5

Largest virus, has 130kbp and can form >100 proteins

Question 6

What are arboviruses?

Answer 6

Infect insects that ingest vertebrae blood, replicate in insect and transmitted by bite

Question 7

What does hepatitis target and how do the types move through the body?

Answer 7

Targets the liver
A & E - enteric
B, C & D - via blood or sex

Question 8

What are the features of SARS?

Answer 8

Severe acute respiratory syndrome, pneumonia, small epidemic pop but fast spreading, controlled by public health measures, grew in cultured vero cells