Lecture 21: Finding Human Genes File

Question 1

Whats the relationship between the distance of the STRs in gene mapping and the % of inheritance ?

Answer 1

The closer the STRs, the higher the % of inheritance

e.g. The nearest STR’s will be inherited at about 100% with phenotype

Question 2

What is a candidate gene ?

Answer 2

a gene that (when mutant) might cause the mutant phenotype we observe

Question 3

What are the two candidate genes for inappropriate aggression ?

Answer 3

Monoamine Oxidase-A (MOXA)

Monoamine Oxidase-B (MOXB)

Question 4

What are the functions of MOXA and MOXB?

Answer 4

they metabolise excess neurotransmitters, which ‘calms’ the fight or flight response

Question 5

What do MOXA and MOXB have in common ?

Answer 5

They both have identical intron/exon structure of 15 exons

They lie next to each other in a head - tail orientation

Question 6

What are the relative activities of MOXA and MOXB ?

Answer 6

MOXA = 85% 
MOXB = 15%

Question 7

How would you make a transgenic MOXA mouse mutant ?

Answer 7

Create a deletion in mouse MOXA, which removes exons 2&3

Question 8

What chromosome is mouse MOXA on ?

Answer 8

X

Question 9

What does MOXA in rhesus monkeys show ?

Answer 9

It shows naturally occuring variation in MOXA activity