Lecture 1: Introduction

Question 1

What is transmission genetics?

Answer 1

How are genes passed from

generation to generation

Question 2

What is functional genetics?

Answer 2

What are genes, what do they

do and how do they do it?

Question 3

What is molecular genetics?

Answer 3

How can we manipulate genes
(DNA) to address questions in
medicine, forensics, evolution
and all aspects of biology

Question 4

Give an example of ancient evidence for genetics

Answer 4

Different breeds of cattle (ayrshire = dairy, Hihgland = beef)

Question 5

What did Mendel work out ?

Answer 5

How genes were inherited and dominance/recessive concept

Question 6

What type of inhertiance in Haemophilia ?

Answer 6

X-linked recessive

Question 7

What does X-linked recessive mean for haemophilia?

Answer 7

Genes linked with condition (Haemophilia) are on X-chromosome.

Males= only one mutation needed (as they are XY)
Females = two mutations needed (as they are XX, only one mutation would not shown in phenotype as wild type is dominant)

Question 8

Changes in F8 gene = ?

Changes in F9 gene = ?

Answer 8

Changes in F8 gene = Haemophilia A

Changes in F9 gene = Haemophilia B

Question 9

F8 gene (A) encodes what?
F9 gene (B) encodes what ?

Answer 9

F8 gene encodes coagulation factor VIII

F9 gene encodes coagulation factor IX

Question 10

Whats the result of mutated F8/F9 gene ?

Answer 10

Blood clots cannot form properly in response to injury. Leads to continuous bleeding.

Question 11

If two different haemophiliacs blood are mixed and the blood clots, what does this mean?

Answer 11

There is two different defects (A and B). Example of complementation

Question 12

Describe another blood deficiency

Answer 12

Afibrinogenaemia - No fibrinogen in blood. Autosomal recessive

Question 13

complementation can be used to work out ______?

Answer 13

how man genes are necessary for each pathway

Question 14

Epistasis can be used to work out _______?

Answer 14

The order of steps in a pathway