Lecture 2-Exam 3 (cardiac) Flashcards
What is the mean arterial pressure equation?
- What drives blood flow?
- What is systolic blood pressure?
- What is diastolic blood pressure?
- The pressure difference across the circulation from the arteries to the veins drives blood flow.
- Systolic blood pressure (SBP) is the peak pressure recorded in the central arterial system and occurs during ventricular ejection.
- Diastolic blood pressure (DBP) is the minimum pressure recorded in the central arterial system and occurs just before the start of ventricular systole.
What is pulse pressure? What is PP reflected by?
Pulse pressure (PP) is the difference between SBP and DBP. PP is reflected by the strength of the arterial pulse wave palpated in the peripheral arteries.
What is the MAP? How are the values weighted?
Mean arterial pressure (MAP) is a time- weighted average of SBP and DBP. Systole occupies about one-third of the cardiac cycle under resting conditions and diastole occupies about two-thirds, giving rise to the following estimate of MAP
Blood pressure measured by cuff inflation in the upper arm of a healthy person is 120/80 mm Hg
* What is the SBP, DBP and PP?
SBP = 120 mm Hg; DBP = 80 mm Hg; and PP = 120 – 80 = 40 mm Hg.
Fill in the values
What are the three determinants of SBP?
SV, Diastolic blood pressure and aortic compliance
Hoe does stroke volume affect SBP?
Increased SV (dt more stretch) increases SBP and PP
How does Diastolic BP relate to SBP?
The absolute value of SBP must be interpreted with respect to DBP, since this is the baseline pressure before systole. For this reason, PP is a useful guide to SV.
How does aortic compliance affect SBP?
If compliance is low (i.e., stiff aorta), the SV produces a large SBP.
What is aortic compliance?
Aortic compliance is not physiologically regulated but often declines with age due to loss of elastic tissue, atherosclerosis, and calcification; SBP typically increases 1 mm Hg for each year after age 60.
What are the three determinants of DBP?
Vascular resistance, runoff of blood from the aorta, diastolic time interval
How does vascular resistance affect DBP?
- Main determinant of DBP
- Blood flow through the circulation continues throughout diastole because the arterial pressure exceeds the venous pressure and due to recoil of the elastic aorta.
- DBP is determined by the size of arteriolar resistance encountered by blood flow. Higher arteriolar resistance (vasoconstriction) increases DBP.
- How does runoff of the blood from the aorta affect the DBP?
- What is an example?
- DBP decreases if blood flow into the circulation during diastole is reduced or decrease in diastolic blood pressure at a reduced heart rate due to increased run-off time (different ways to say it)
- Aortic valve insufficiency is an example where aortic pressure rapidly decreases during diastole because backflow of blood into the left ventricle reduces forward flow into the circulation.
How does diastolic time interval affect DBP?
- Aortic pressure decreases with time between heart beats because blood continues to flow into the circulation from the aorta throughout diastole.
- DBP is lower when the HR is slow because more time elapses between beats. DBP is higher at faster heart rates because there is less time for a decline in aortic pressure between beats aka increases DBP with increase HR dt reduced run off time
What happens when there is a slower HR? (What happens to SV, PP, DBP?)
CO is the same
What happens when there is a faster HR? (What happens to SV, PP, DBP?)
CO is same
What is total peripheral resistance?
The collective resistance to blood flow presented by the systemic vasculature is called systemic vascular resistance, or total peripheral resistance (TPR).
MAP=CO X TPR
Systemic vascular resistance is mainly determined by what?
changes in the diameter of the arterioles
- What is vaccular tone?
- What is arteriolar tone affected by?
- How is TPR increased?
i. Arterioles are partially constricted under normal physiologic conditions, called vascular tone, and are the sites of active regulation of blood flow in the circulation.
ii. Arteriolar tone is affected by many factors, including sympathetic tone and hormones and endothelial and metabolic factors.
iii. Systemic vascular resistance is increased by vasoconstriction and reduced by vasodilation.
Large compliance in veins allows what?
Large compliance in the veins allows them to accommodate high volumes with little change in pressure.
o Systemic veins are ~20 times more compliant than systemic arterie
What happens in arteries when there are changes in volume and pressure?
In arteries, small changes in volume cause large changes in pressure…and large changes in pressure result in a small degree of expansion
What is venous return?
is the volume of blood returning to the central venous compartment (i.e., thoracic venae cavae and right atrium) per minute.
- What is central venous pressure?
- What does low CVP promotes?
- CVP has a strong influence on what?
Central venous pressure (CVP) is the pressure of venous blood in the thoracic vena cava and the right atrium.
* Low CVP promotes venous return into the central venous compartment, whereas high CVP reduces venous return.
* CVP has a strong influence on cardiac preload and, through the Frank-Starling mechanism, determines ventricular SV.