Lecture 2 Action potential Flashcards
Where is potassium K+ concentration higher
Inside the cell
Intracellular
Where is the Na+ ions higher
Outside of cell
Extracellular
Where is cl higher
Extracellular outside
Where is ca higher
Outside
Extracellular
What creates the membrane potential
Ion concentration between Extracellular membrane fluid and Intracellular Membrane fluid
And selectively permeable cell membrane
What is the effect of K ions leaving the cell
Inside of cell more negative outside more positive
Resting potentials
Charge across the membrane at rest
Ie ion channels not open
Hyperpolarisation
Membrane potential MORE negative
Dip in graph
Net increase in negative charge inside cell
Depolarisation
Membrane potential less negative
Peak in graph
Net decrease in negative charge inside cell
Repolarisation
Membrane potential returns to rest
What does cytoplasmic Na bind to
Sodium potassium pump
What enzyme used in membrane potential
Na/k ATPase
What stimulates the phosphorylation of the pump by ATP
Na binding
Effect of phosphorylation
Protein change shape = na outside
Extracellular K binding
Protein triggering release of phosphate
