Lecture 2 8/27/24 Flashcards
What is polychromasia?
morphologic description of what a reticulocyte looks like on routine blood smear
What do spherocytes indicate?
immune-mediated hemolytic anemia
What are spherocytes?
RBCs with membrane-bound antibodies that are removed by macrophages; removal of part of the membrane causes the cells to have a spherical shape
What does agglutination indicate?
immune-mediated hemolytic anemia
What is rouleaux?
linear arrangements of RBCs due to increased globulins
What are heinz bodies?
a projection off of a RBC that indicates oxidant injury
What are eccentrocytes?
RBCs with a white “fingernail” appearance that indicates oxidant injury
What are schistocytes?
torn or fragmented RBCs
What are the potential causes of schistocytes?
-disseminated intravascular coagulation
-hemangiosarcoma
-cardiac disease
What is basophilic stippling?
diffuse stippling of RBCs on a routinely stained blood smear
What are the potential causes of basophilic stippling?
-regenerative anemia in ruminants
-lead toxicity in any species
What are the mechanisms of anemia?
-hemorrhage
-hemolysis
-decreased RBC production in the bone marrow
Which mechanisms of anemia are regenerative?
-hemorrhage
-hemolysis
Which mechanism of anemia is non-regenerative?
decreased bone marrow production of RBCs
What does it mean for an anemia to be regenerative?
bone marrow responds appropriately to RBC loss by increasing RBC production