Lecture 17 - Brain and Cranial Nerves Flashcards
What parts of the brain are proportionally larger in humans compared to other primates?
Frontal and parietal lobes
-humans have largest relative brain size compared to other primates
Which germ layer forms the central nervous system (and skin)?
Ectoderm
Neurulation
1st: gene signaling from the notochord causes rapid growth in nearby ectoderm
2nd: thickening neural crest comes together, forming neural tube
What does the prosencephalon give rise to?
Prosencephalon gives rise to forebrain structures.
- Telencephalon = Cerebrum
- Diencephalon = Thalamus/Hypothalamus
What does the mesencephalon give rise to?
Midbrain
What does the rhombencephalon give rise to?
Rhombencephalon gives rise to hindbrain structures.
- Metencephalon = Pons/Cerebellum
- Myelencephalon = Medulla Oblongata
Synaptic Pruning
Little used dendritic connections are selectively pruned at several stages during adolescence, continuing into adulthood.
*Schizophrenia may be due to excessive pruning
Which arteries provide all blood supply to the brain?
Carotid and vertebral arteries.
- Vertebral arteries pass through foramen magnum
- Internal carotid supplies blood to brain (enters through carotid canal on temporal bone)
- External carotid supplies blood to face and scalp
Circle of Willis
- circular arterial connection at the base of the skull
- forms an anastomosis
*aneurysms most commonly formed here
Anastomosis
- series of connections between blood vessels
- provides redundant blood flow in case of blockages
The brain takes up 2% of body mass but 20% of basal metabolic consumption. Why?
The brain is so expensive because we need to maintain ion cencentration gradients for neuron firing.
Cerebrospinal Fluid
- brain is suspended in CSF
- fills the subarachnoid space
- provides buoyancy and cushion for the brain
- produced and stored in the ventricles, connected spaces/canals located in the center of the brain
- drains into the venous system
What holds the veins (sinuses) of the brain in place?
Dural bands
CN I
Olfactory Nerve
- sensory (smell)
- passes through the cribiform plate on the ethmoid bone
- origintes at the cerebrum
CN II
Optic Nerve
- sensory (sight)
- passes through the optic canal on the sphenoid bone
- originates at thte cerebrum
CN III
Oculomotor Nerve
- motor: eye and eyelid movement, pupil constriction, lens deformation (superior rectus, medial rectus, inferior rectus, inferior oblique)
- autonomic (parasympathetic) innervation of the constrictor pupillae and ciliary muscles
- passes through superior orbital fissure on the sphenoid
- originates at the midbrain
CN IV
Trochlear Nerve
- motor: eye movement
(voluntary: superior oblique muscle) - passes through superior orbital fissure on the sphenoid
- originates at the midbrain