Lecture 17

Question 1

What is chronic inflammation with macrophages called?

Answer 1

histiocytic

Question 2

What is chronic inflammation characterized by epithelioid macrophages and MNGC called?

Answer 2

granulomatous

Question 3

What is chronic inflammation characterized by lymphocytes called?

Answer 3

lymphocytic

Question 4

What is chronic inflammation characterized by plasma cells called?

Answer 4

plasmacytic

Question 5

What is chronic inflammation characterized by lymphocytes and plasma cells called?

Answer 5

lymphoplasmacytic

Question 6

What is chronic inflammation containing neutrophils and epithelioid macrophages called?

Answer 6

pyogranulomatous

Question 7

Explain the characteristics of granulomatous and granuloma and differentiate between them:

Answer 7

These are characterized primarily by fused macrophages that have formed multi-nucleated giant cells (Langerhans giant cells). Granulomatous = diffuse
Granuloma = nodular

Question 8

Describe the pathology of a granuloma going from the inside to the outside:

Answer 8

Center: central caseous necrosis due to hypoxia and free radical injury, central clusters of epithelioid macrophages, fusion of epithelioid macrophages to form Langerhans giant cells

Middle layer: T lymphocytes (could include plasma cells)

Rimmed by: fibroblasts (older lesions) and also connective tissue

Question 9

What is it important to eliminate tuberculosis as a differential diagnosis?

Answer 9

It has significant public health significance