Lecture 13 Flashcards
What is a transudate?
non-inflammatory increase in interstitial fluid (ISF)
What is a modified transudate?
a transudate that is high in protein but low in cells
What is oedema?
non-inflammatory increase in ISF
What is an exudate?
inflammatory increase in ISF
What is an effusion?
exudate into a body cavity
What is the process that is involved in leukocyte extravasation?
- Selectins
- Integrins
- Adhesion molecules
- Transmigration
What are the cell involved in a bacterial cellular response?
- Neutrophils
- Macrophages
- Lymphocytes
What are the cells that are involved in a viral cellular response?
- T lymphocytes
- B lymphocytes
- NK cells
What are the cells that are involved in an allergic response?
- Mast cells
- Eosinophils
- Lymphocytes
What are the cells that are involved in a parasite response?
- Eosinophils
- Macrophages
- Lymphocytes
What are the main types of cells that secrete histamine?
Mast cells
What are the main types of cells that secrete prostaglandins and leukotrienes?
All leukocytes
What are the two systems that are directly activated by Factor XII (Hageman Factor)?
Kinin system (bradykinin) and the coagulation/fibrinolysis system
What are the main components involved in complement activation?
C3a, C5a, C3b, C5b
What are the main arachidonic acid metabolites and what secretes them?
Arachidonic acid metabolites = Thromboxane (TxA), Prostaglandins (PG), Leukotrienes (LT), Lipoxins, Resolvins
What are the do the vasoactive amines come from?
These are preformed in cytoplasmic granules (Histamine and Serotonin). Come from mast cells and granulocytes.
What are the main cytokines and chemo-kines and where do they come from?
Come from lymphocytes and macrophages. They are newly synthesized and include IL-1b, IL-6 and TNFa
