Lecture 15 - Sleep Flashcards

1
Q

What is a sleep laboratory?

A

A sleep laboratory is a controlled environment where researchers monitor a person’s brain and body activity during sleep studies.

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2
Q

How is brain activity measured during sleep?

A

Brain activity is measured using an EEG (Electroencephalogram), where electrodes are placed on the scalp to capture different types of brain waves associated with various sleep stages.

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3
Q

What does an EMG measure in a sleep study?

A

An EMG (Electromyogram) measures muscle activity by placing electrodes on the chin, helping to determine when muscles relax during sleep.

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4
Q

What is the purpose of an EOG in sleep research?

A

An EOG (Electro-oculogram) tracks eye movements using electrodes near the eyes, which are particularly noticeable during certain sleep stages, like REM sleep.

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5
Q

What are beta waves and when are they observed?

A

Beta waves (13-30 Hz) are brainwave patterns that occur when a person is awake, alert, and actively engaged in cognitive tasks. They are characterized by high frequency (fast brain activity) and low amplitude (small fluctuations in the electrical signals), which means the brain is processing information with quick, scattered activity. Essentially, beta waves reflect a state of heightened mental focus and activity.

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6
Q

What do alpha waves indicate about a person’s state?

A

Alpha waves (8-13 Hz) indicate a relaxed, awake state, such as when someone is quietly resting with their eyes closed.

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7
Q

When do theta waves typically occur?

A

Theta waves (4-8 Hz) appear when someone is drowsy or lightly asleep and become more prominent in the early stages of sleep.

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8
Q

Describe delta waves and their significance in sleep.

A

Delta waves, which are low-frequency (<4 Hz) and high-amplitude brain waves, occur during the deepest stages of sleep, known as slow-wave sleep. They indicate synchronized neural activity, meaning that large groups of neurons are firing together in a coordinated way. Delta waves are important for restorative sleep, aiding in physical recovery and memory consolidation.

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9
Q

What characterizes REM sleep?

A

REM sleep (Rapid Eye Movement sleep) is a stage of sleep marked by desynchronized brain activity, which resembles the brain’s activity when we’re awake. During this phase, we experience rapid eye movements, vivid dreams, and muscle paralysis (which prevents us from acting out our dreams). Despite being asleep, the brain is highly active and uses a lot of oxygen, similar to when we’re awake.

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10
Q

How does the EEG pattern change during slow-wave sleep?

A

During slow-wave sleep, which occurs in stages 3 and 4 of non-REM sleep, the EEG (electroencephalogram) shows large amplitude, low-frequency waves. This pattern reflects synchronized neuronal activity—where groups of neurons fire together—resulting in low brain metabolic activity. This stage of sleep is considered the most restorative because the brain is less active and allows for physical recovery and memory consolidation.

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11
Q

What happens to muscle tone during REM sleep?

A

During REM sleep, muscle activity drops significantly, causing muscles to become limp, which can lead to animals falling off surfaces if they sleep on narrow platforms.

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12
Q

What effects does prolonged sleep deprivation have on rats?

A

Prolonged sleep deprivation in rats, achieved by preventing sleep using EEG detection (which monitors brain activity), causes problems with regulating body temperature and metabolism, leading to weight loss, serious health issues, and eventually death after two to three weeks.

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13
Q

What are some effects of not getting enough sleep?

A

Effects of sleep deprivation include feeling tired and sluggish, mental decline, poor reactions and judgment, mood and behavior issues, memory and learning problems, health risks, sleep debt, and microsleeps.

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14
Q

What is sleep debt?

A

Sleep debt is the accumulated amount of sleep loss that the body needs to repay by sleeping more later, typically occurring when sleep is missed.

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15
Q

How does lack of sleep impact your mood and behavior?

A

Lack of sleep raises stress hormones, leading to increased moodiness, impulsiveness, and emotional swings.

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16
Q

What are microsleeps, and what happens during them?

A

Microsleeps are brief periods of sleep lasting a few seconds that occur when someone is extremely sleep-deprived, during which they may become unaware of their surroundings.

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17
Q

Why is sleep critical for survival?

A

Sleep is vital for physical and mental health, aiding in cognitive functions, emotional stability, memory consolidation, and overall well-being.

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18
Q

How do dolphins sleep differently from humans?

A

Dolphins sleep by having one half of their brain sleep at a time, allowing them to remain somewhat alert and aware of their surroundings.

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19
Q

How much sleep do newborns typically need compared to adults?

A

Newborns sleep about 16 hours a day, equally dividing their time between REM and NREM sleep, while adults average about 7 hours, spending most of that time in NREM sleep.

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20
Q

How does sleep duration vary between predator and prey animals?

A

Predators tend to sleep longer and more uninterrupted, while prey animals usually sleep in short bursts to remain vigilant.

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21
Q

What is the general relationship between animal size and sleep duration?

A

Smaller animals tend to sleep more than larger animals, indicating that species with lower body weight usually have longer sleep durations.

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22
Q

How does metabolic rate relate to body weight in animals?

A

Larger animals have a higher total metabolic rate because they have more cells and larger organs, meaning they burn more energy overall. However, on a per-cell basis, their metabolic rate is lower compared to smaller animals. This is because smaller animals have a higher surface area-to-volume ratio, which leads to more heat loss and requires their cells to burn more energy to maintain body temperature. In short, larger animals use more energy overall, but their cells use less energy individually than those of smaller animals.

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23
Q

How does body size influence sleep patterns and behaviors in animals?

A

Larger animals tend to have slower metabolism, longer lifespans, less sleep overall, and longer sleep cycles, which suggests an evolutionary advantage in energy efficiency.

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24
Q

What is a possible hypothesis for the connection between body size and sleep duration?

A

The hypothesis suggests that larger body sizes provide advantages like better heat retention and efficient nutrient and waste distribution, leading to reduced cellular work and, consequently, less need for sleep.

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25
Q

How might sleep serve a restorative purpose for the body?

A

Since total sleep time is linked to metabolic functions and energy efficiency, it suggests that sleep is essential for restoring or recharging the body’s systems.

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26
Q

What is one main theory about why sleep is important for recovery?

A

The recovery theory suggests that sleep helps us recover from physical activity or mental effort, implying that individuals who exert themselves physically or mentally should need more sleep.

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27
Q

Why do people who exercise or are restricted in movement not necessarily sleep more?

A

Evidence shows that increased physical activity or being restricted in movement does not lead to a significant increase in sleep duration, contradicting the recovery theory.

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28
Q

What small physical changes occur in the body during sleep?

A

During sleep, the heart rate and blood pressure slightly decrease, but the body’s energy usage doesn’t drop drastically compared to when it’s simply at rest while awake.

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29
Q

How does sleep relate to brain processing, learning, and memory?

A

Sleep may allow the brain to reorganize and save memories, facilitating better memory retention and processing that is challenging to achieve while awake.

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30
Q

What types of memory are improved by different stages of sleep?

A

Deep (slow-wave) sleep enhances declarative memory (facts), while REM (dream) sleep is linked to improved procedural memory (skills).

31
Q

What changes occur in the brain during sleep that support memory processing?

A

During sleep, the brain strengthens memory by reorganizing information and reinforcing synaptic connections. This process occurs through gene activity that promotes the formation of new synaptic proteins and the synchronization of brain waves, especially during deep sleep stages. These coordinated brain rhythms, particularly slow-wave sleep, help consolidate memories by transferring them from the hippocampus to the cortex for long-term storage.

32
Q

What is the waste removal theory regarding sleep?

A

The waste removal theory posits that sleep is necessary for clearing waste products from the brain, with sleep duration relating to factors such as body size and metabolic needs.

33
Q

How does sleep facilitate waste removal in the brain?

A

During sleep, astrocytes (support cells for neurons and the blood brain barrier) shrink, creating more space for cerebrospinal fluid (CSF) to move through the brain and effectively wash away waste products.

34
Q

How is the glymphatic system involved in waste clearance during sleep?

A

The glymphatic system utilizes cerebrospinal fluid (CSF) to clear waste from the brain by flowing through spaces around neurons and transporting waste to blood vessels for removal.

35
Q

Why might larger animals sleep less despite having larger brains?

A

Larger brains may provide an advantage in waste clearance efficiency, allowing larger animals to require less sleep for the same level of waste removal compared to smaller animals.

36
Q

What evolutionary trade-off might explain why animals don’t just evolve bigger brains for constant waste clearance?

A

Instead of evolving bigger brains for continuous waste clearance, animals may have prioritized brain efficiency. This led to the need for sleep, which allows the brain to remove waste effectively.

37
Q

Imagine a scenario where an animal is kept awake for extended periods. What might happen to its cognitive function and waste clearance?

A

The animal could experience impaired cognitive function due to disrupted memory processing and accumulation of waste products in the brain, which normally would be cleared during sleep.

38
Q

What are circadian rhythms?

A

Circadian rhythms are 24-hour cycles that regulate behavior and bodily functions, such as sleep patterns and body temperature, controlled by internal biological clocks.

39
Q

How do internal biological clocks function in the absence of light?

A

Internal biological clocks continue to run in the absence of light, but exposure to light helps align them precisely with the 24-hour day.

40
Q

What effect do changing light patterns have on nocturnal animals like rats?

A

Changing light patterns can quickly shift the activity schedule of nocturnal animals, causing them to adjust their behavior according to the new light cues.

41
Q

What is the suprachiasmatic nucleus (SCN)?

A

The suprachiasmatic nucleus (SCN) is a region in the hypothalamus that serves as the brain’s main clock, controlling circadian rhythms by receiving signals from the retina.

42
Q

What happens to circadian rhythms if the SCN is damaged?

A

Damage to the SCN disrupts circadian rhythms, affecting the timing of processes like sleep and hormone release, though the total amount of sleep remains unchanged.

43
Q

How do specific genes contribute to circadian rhythms?

A

Certain genes are involved in the regulation of circadian rhythms by producing proteins that follow a 24-hour cycle. These proteins gradually build up during the day and eventually reach levels that stop the genes from producing more of them. As the proteins break down, the cycle resets, starting the process over again. This feedback loop ensures the rhythm of the body’s internal clock, helping regulate sleep, wakefulness, and other daily biological processes.

44
Q

What is advanced sleep phase syndrome?

A

Advanced sleep phase syndrome is a disorder caused by a mutation in the per2 gene, which controls the body’s internal clock. This mutation causes the sleep-wake cycle to shift earlier, leading to an earlier-than-usual bedtime and wake-up time—typically about 4 hours earlier than normal. As a result, individuals with ASPS often feel sleepy in the early evening and wake up very early in the morning, sometimes even before sunrise.

45
Q

What is delayed sleep phase syndrome?

A

Delayed sleep phase syndrome is a condition caused by a mutation in the per3 gene that shifts the sleep-wake cycle back by 4 hours, resulting in a tendency to sleep late and wake late.

46
Q

What does the sleep molecule hypothesis propose?

A

The sleep molecule hypothesis suggests that waste products build up in the brain during wakefulness, causing drowsiness, and that sleep helps clear these molecules, such as adenosine.

47
Q

How does caffeine affect sleepiness?

A

Caffeine blocks adenosine receptors in the brain, preventing the sleepiness that results from high levels of adenosine, which increases during the day.

48
Q

Which neurotransmitters promote wakefulness?

A

Wakefulness is promoted by neurotransmitters such as:
- Serotonin: involved in regulating mood and arousal
- Norepinephrine: helps with alertness and focus
- Acetylcholine: plays a role in attention and memory
- Orexin: regulates arousal and appetite
- Histamine: promotes wakefulness and increases alertness.
These neurotransmitters are more active during wakefulness and less active during deep sleep.

49
Q

How can antihistamines affect alertness?

A

Antihistamines can cause drowsiness by blocking the action of histamine, a neurotransmitter that promotes wakefulness. Older antihistamines, in particular, can cross the blood-brain barrier and affect the brain, leading to sedation and making you feel sleepy.

50
Q

What role does the ventral lateral preoptic area (vlPOA) play in sleep?

A

The ventral lateral preoptic area (vlPOA) is located in the hypothalamus and plays a critical role in sleep regulation. It promotes sleep by releasing inhibitory neurotransmitters like GABA to suppress activity in wake-promoting regions of the brain, such as the arousal centers in the brainstem and hypothalamus. When the vlPOA is active, it helps induce drowsiness and maintain sleep, while damage to this area can lead to difficulties falling asleep or staying asleep, contributing to insomnia.

51
Q

What is reciprocal inhibition in the context of sleep and wakefulness?

A

Reciprocal inhibition is the mechanism where vlPOA neurons send signals to turn off wake-promoting neurons, while those neurons also inhibit vlPOA activity, allowing only one group to be active at a time.

52
Q

How does the strength of wake-promoting neurons affect sleep?

A

If wake-promoting neurons are stronger than vlPOA neurons, the animal remains awake; when vlPOA neurons dominate, sleep begins.

53
Q

What is adenosine and how does it affect the brain?

A

Adenosine is a neurotransmitter-like molecule that accumulates in the brain during wakefulness, particularly in areas like the basal forebrain and hippocampus. As adenosine builds up throughout the day, it binds to adenosine receptors (primarily A1 receptors) on neurons, inhibiting their activity. This gradual buildup increases sleep pressure, making you feel more tired and promoting the transition into sleep. In the brain, adenosine also reduces the activity of excitatory neurotransmitters like glutamate and enhances the activity of inhibitory neurotransmitters like GABA, ultimately promoting relaxation and sleep.

54
Q

How does adenosine influence sleep-promoting neurons?

A

As adenosine accumulates, it triggers sleep-promoting vlPOA neurons and inhibits the neurons that usually keep us awake, particularly those releasing acetylcholine (ACh).

55
Q

What role does the suprachiasmatic nucleus (SCN) play in sleep regulation?

A

The SCN serves as the body’s master clock, sending signals that influence when we sleep or wake, working in conjunction with adenosine levels.

56
Q

Describe the “flip-flop” mechanism in sleep and wakefulness.

A

The “flip-flop” mechanism refers to the brain’s ability to rapidly switch between sleep and wakefulness, controlled by the balance of signals from the suprachiasmatic nucleus (SCN), which regulates the circadian rhythm, and the buildup of adenosine. When you are awake, adenosine levels gradually increase, promoting sleep. The SCN, influenced by light and time of day, helps synchronize the internal clock. When adenosine levels become high enough and the SCN signals for sleep, a switch occurs in the brain that promotes sleep. However, when you wake up, the SCN signals for alertness, and adenosine levels decrease, helping the brain switch back to wakefulness. The “flip-flop” nature ensures a clear transition between states, preventing both sleep and wakefulness from being active at the same time.

57
Q

What is the role of orexin in maintaining wakefulness?

A

Orexin is a neurotransmitter produced by neurons in the lateral hypothalamus, and it plays a key role in promoting and maintaining wakefulness. It helps regulate the transition between sleep and wakefulness, becoming active when the body needs to stay alert, such as during periods of physical activity or attention. Orexin also supports the stability of wakefulness, preventing unwanted sleep episodes. A deficiency in orexin is associated with narcolepsy, a disorder where individuals experience excessive daytime sleepiness and sudden, uncontrollable episodes of sleep.

58
Q

What is narcolepsy?

A

Narcolepsy is a rare sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks, often due to the loss of orexin neurons in the hypothalamus.

59
Q

What is sleep paralysis?

A

Sleep paralysis is a symptom of narcolepsy where a person experiences temporary inability to move, often accompanied by vivid, dream-like visions, occurring just before sleep or upon waking.

60
Q

What is cataplexy, and what triggers it?

A

Cataplexy is a sudden loss of muscle control triggered by strong emotions (like laughter or anger), caused by an abnormal activation of REM sleep mechanisms while awake, leading to brief muscle paralysis.

61
Q

What are the two main components of the sleep-wake system?

A

The sleep-wake system consists of the vIPOA (ventrolateral preoptic area), which acts as the “sleep switch,” and the arousal system, which includes neurotransmitters like serotonin and orexin that keep us alert.

62
Q

What are the two systems involved in REM sleep regulation?

A

The “dream-on” system (SLD) triggers REM sleep, while the “dream-off” system (vIPAG) helps shut off dreaming.

63
Q

How do orexin neurons contribute to sleep-wake stability?

A

Orexin neurons stabilize the sleep-wake system; insufficient orexin can lead to sudden sleep-like states, as seen in cataplexy.

64
Q

What are the potential consequences of the “flip-flop” system in sleep regulation?

A

The “flip-flop” system can create “grey areas” between wakefulness and sleep, resulting in vivid dreams, hallucinations, or confusion about whether one is awake or dreaming.

65
Q

What is insomnia?

A

Insomnia is a sleep disorder where a person has trouble falling or staying asleep, affecting about 25% of people occasionally and 9% regularly.

66
Q

What are Fatal Familial Insomnia (FFI) and Sporadic Fatal Insomnia (SFI)?

A

FFI and SFI are very rare sleep disorders that cause a gradual loss of the ability to sleep, leading to hallucinations, confusion, and eventually death due to brain damage in areas like the thalamus and hypothalamus.

67
Q

What are non-REM parasomnias?

A

Non-REM parasomnias are unusual behaviors that occur during non-REM sleep or when the brain is partially awake, often without the individual’s awareness.

68
Q

What are some examples of behaviors associated with non-REM parasomnias?

A

Examples include sleepwalking, talking, groaning, crying, eating, masturbating, and teeth grinding, often occurring in children and typically short in duration.

69
Q

How are sleep terrors characterized?

A

Sleep terrors are characterized by extreme panic upon waking, which may involve screaming and sudden movements, and the person may not remember the episode; they are more common in individuals with PTSD.

70
Q

What is REM Sleep Behavior Disorder?

A

REM Sleep Behavior Disorder is a condition where individuals do not experience the typical paralysis during REM sleep, allowing them to act out their dreams; it is considered a neurodegenerative disorder often associated with genetic links and conditions like Parkinson’s disease.

71
Q

If a child sleepwalks and occasionally eats while asleep, what type of disorder might they be experiencing?

A

They might be experiencing non-REM parasomnia, as these behaviors occur during non-REM sleep.

72
Q

Imagine a person who suddenly wakes up screaming and is confused about where they are, yet they do not remember the event the next day. What sleep disorder might they be experiencing?

A

This person might be experiencing sleep terrors, which involve extreme panic and lack of memory for the event.

73
Q

A person with REM Sleep Behavior Disorder acts out their dreams, sometimes harming themselves or their partner. What does this indicate about their sleep process?

A

This indicates that the person is not experiencing the usual paralysis during REM sleep, allowing for physical activity while dreaming.

74
Q
A