Lecture 13 - Hunger and Thirst Flashcards

1
Q

What is homeostasis?

A

Homeostasis is the body’s process for maintaining internal conditions, such as temperature and water levels, within a range that supports survival.

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2
Q

Why do cells need a stable temperature and steady supply of food and water?

A

Cells need a stable temperature and a consistent supply of food and water to function properly; without these, they cannot survive.

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3
Q

How do animals survive in diverse environments?

A

Animals have systems that help them maintain stable internal conditions, allowing them to survive in various environments, from hot and dry to cold and wet.

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4
Q

What is unconscious temperature regulation in warm-blooded animals?

A

Unconscious temperature regulation in warm-blooded animals involves automatic processes that maintain a stable internal temperature, such as shivering, blood vessel constriction, sweating, and blood vessel expansion.

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5
Q

How does the body respond when it gets too cold?

A

When it’s too cold, the body increases metabolic rate, causes shivering, and constricts blood vessels near the skin to retain heat.

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6
Q

How does the body cool down when it gets too hot?

A

The body cools down by sweating or panting, which helps heat escape through evaporation, and by expanding blood vessels near the skin to release heat.

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7
Q

How do cold-blooded animals regulate their temperature?

A

Cold-blooded animals rely mostly on their environment to regulate their temperature, as they cannot adjust their internal temperature as effectively as warm-blooded animals.

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8
Q

What motivates conscious temperature regulation?

A

Conscious temperature regulation is motivated by discomfort, which creates a “need state” that encourages actions like seeking warmth or cooling down.

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9
Q

Why do we sometimes anticipate relief or pleasure when adjusting the temperature?

A

Anticipation of relief or pleasure can motivate us to act, such as putting on a sweater before going outside, even if we don’t feel cold yet.

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10
Q

Imagine you’re outside on a cold day without a jacket and begin to shiver. Which processes are involved in helping you stay warm?

A

The body would increase metabolic rate, trigger shivering, and constrict blood vessels near the skin to reduce heat loss and protect core temperature.

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11
Q

How does homeostasis help regulate thirst?

A

Homeostasis regulates thirst by monitoring water levels in the body; when levels are low, it prompts us to drink water to restore balance.

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12
Q

What are the steps in the body’s response to water loss?

A

When water is lost, the body detects low water levels, triggers thirst, signals the brain when drinking starts, and eventually provides a “stop” signal when enough water is consumed.

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13
Q

What role do stomach signals play in thirst regulation?

A

Stomach signals help regulate thirst by informing the brain as the stomach fills with fluid, providing early feedback to reduce the drive to drink and prevent overhydration before blood hydration levels actually rise.

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14
Q

What is osmometric thirst?

A

Osmometric thirst is the sensation of thirst that arises when there is not enough water inside the body’s cells.

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15
Q

What is volumetric thirst?

A

Volumetric thirst occurs when there isn’t enough blood or liquid in the circulatory system.

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16
Q

How does the body signal us to stop drinking once we’ve had enough?

A

When the body has absorbed enough water and the fluid balance is restored, the brain receives signals indicating satiety (fullness). These signals come from stretch receptors in the stomach and changes in blood osmolarity, which tell us that we’ve had enough to drink, prompting us to stop.

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17
Q

What is the definition of osmometric thirst?

A

Osmometric thirst is thirst that arises when there is an insufficient amount of water inside the body’s cells.

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18
Q

What is the definition of volumetric thirst?

A

Volumetric thirst is thirst that occurs when there is a low volume of blood or liquid in the circulatory system.

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19
Q

If you’ve been sweating after exercise, which type of thirst is most likely to be triggered?

A

Volumetric thirst would likely be triggered, as sweating can lead to a reduction in blood volume, prompting the need to drink.

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20
Q

How might you experience osmometric thirst on a very hot day?

A

On a hot day, you might experience osmometric thirst due to dehydration, as water inside your cells decreases from excess sweating or lack of fluid intake.

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21
Q

What is tonicity?

A

Tonicity refers to the balance of solutes inside and outside cells, which affects the movement of water.

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22
Q

What is diffusion?

A

Diffusion is the movement of solutes from areas of higher concentration to areas of lower concentration.

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23
Q

What is osmosis?

A

Osmosis is the movement of water toward areas where solutes are more concentrated.

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24
Q

What is an isotonic solution, and how does it affect cells?

A

An isotonic solution has the same concentration of solutes inside and outside the cell, resulting in balanced water movement.

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25
Q

What is a hypotonic solution, and how does it affect cells?

A

In a hypotonic solution, there are fewer solutes outside the cell, causing water to move into the cell, making it swell.

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26
Q

What is a hypertonic solution, and how does it affect cells?

A

In a hypertonic solution, there are more solutes outside the cell, causing water to move out of the cell, making it shrink.

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27
Q

How does osmometric thirst develop?

A

Osmometric thirst occurs when hypertonic (salty) conditions outside cells cause them to lose water and shrink, leading to dehydration.

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28
Q

What are the main body fluid compartments, and how are they distributed?

A

The main fluid compartments are intracellular fluid (67% inside cells) and extracellular fluid, which includes cerebrospinal fluid (less than 1%), intravascular fluid (7% in blood plasma), and interstitial fluid (26% between cells).

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29
Q

How does the body maintain fluid balance after drinking water?

A

Drinking water makes extracellular fluid less concentrated, causing water to flow into cells and expand them. Any extra water is eliminated through urine.

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30
Q

How does the body respond when you eat salty food?

A

Eating salty food makes extracellular fluid more concentrated, causing water to leave cells and shrink them, which triggers thirst to help dilute the saltiness.

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31
Q

What role do osmoreceptors play in thirst?

A

Osmoreceptors are neurons that detect changes in cell size. When they shrink due to hypertonic conditions, they signal the brain to trigger thirst.

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32
Q

What triggers volumetric thirst?

A

Volumetric thirst is triggered by a loss of blood or other fluids that reduces blood volume, signaling the body to increase fluid intake to restore blood levels.

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33
Q

Why does blood loss lead to feelings of extreme thirst?

A

Blood loss lowers blood volume, prompting the body to signal for fluids to restore proper volume for heart function.

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34
Q

How does low blood pressure lead to the release of renin?

A

When blood pressure drops, especially due to a decrease in blood volume (like from dehydration or blood loss), the kidneys detect this through sensors in the blood vessels. In response, the kidneys release renin. Renin starts a process that helps raise blood pressure by constricting blood vessels and prompting the kidneys to retain sodium and water, which increases blood volume. This chain of events helps restore normal blood pressure.

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35
Q

What does renin do in the body?

A

Renin triggers the formation of angiotensin II, which helps the body retain sodium and water, raises blood pressure, and increases salt and water cravings.

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36
Q

What happens when the body detects hypovolemia (low blood volume)?

A

Blood flow to the kidneys decreases, leading to the release of renin, which combines with angiotensinogen to form angiotensin II, triggering responses to restore blood volume.

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37
Q

What is the role of angiotensin II in the body?

A

Angiotensin II helps the body retain sodium and water, raises blood pressure, and stimulates salt cravings and the urge to drink fluids.

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38
Q

What brain region is primarily involved in the sensation of thirst?

A

The anteroventral tip of the third ventricle (AV3V region) in the hypothalamus is primarily involved in controlling thirst sensations.

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39
Q

Which two brain regions show increased activity when a person feels thirsty?

A

The AV3V region of the hypothalamus and the anterior cingulate cortex show increased activity when a person feels thirsty.

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40
Q

How does drinking water quickly reduce the sensation of thirst, even before reaching the cells that need it?

A

Drinking reduces thirst sensations by activating cold sensors in the mouth and sensory fibers in the stomach, which signal the brain that drinking is happening, even before the water reaches thirsty cells.

41
Q

How does the body learn that drinking water will relieve thirst over time?

A

The body learns through repeated experiences that drinking water reduces thirst, so just the act of drinking can immediately decrease the feeling of thirst.

42
Q

What are the three main nutrients in food that provide energy for the body?

A

The three main nutrients in food that provide energy are carbohydrates (sugars), lipids (triglycerides), and amino acids (proteins).

43
Q

How does the pancreas regulate blood glucose levels when they are high?

A

When blood glucose is high, the pancreas releases insulin, which helps store excess glucose as glycogen in the liver and muscles.

44
Q

What hormone does the pancreas release when blood glucose levels are low, and what does it do?

A

When blood glucose is low, the pancreas releases glucagon, which converts glycogen back into glucose for energy use.

45
Q

What is glycogen, and how much energy can it store?

A

Glycogen is a form of stored glucose, providing a short-term energy reserve of up to 2000 calories.

46
Q

Which cells in the body can absorb glucose directly without the need for insulin?

A

Brain cells can absorb glucose directly, regardless of blood glucose levels, without the need for insulin.

47
Q

How do most body cells use glucose after a meal, and what energy source do they switch to later?

A

After a meal, most body cells use glucose for energy with the help of insulin. About two hours later, when insulin levels drop, they switch to using ketones (from fats) as an energy source.

48
Q

What are blood lipids, and which types of molecules are included in them?

A

Blood lipids are fats in the bloodstream, including fatty acids and triglycerides, which serve as stored energy.

49
Q

How does insulin help store fat in the body?

A

Insulin directs fatty acids into fat cells, where they are converted into triglycerides for long-term energy storage.

50
Q

What is the role of glucagon in fat breakdown?

A

Glucagon breaks down triglycerides into fatty acids, releasing them into the blood for energy when glucose is low.

51
Q

What is a triglyceride composed of?

A

A triglyceride consists of one glycerol molecule and three fatty acid molecules.

52
Q

How does the liver use glycerol and fatty acids during low glucose levels?

A

During low glucose levels, the liver converts glycerol into glucose and fatty acids into ketones, which provide an alternative energy source.

53
Q

What happens to the body’s energy use when insulin is active versus when glucagon is active?

A

When insulin is active, cells use glucose for energy, and extra glucose is stored. When glucagon is active, glycogen is broken down into glucose for brain cells, and other body cells switch to using ketones for energy.

54
Q

Imagine someone has just eaten a meal rich in carbohydrates. Which hormone will be primarily active, and what effect will it have on blood sugar?

A

Insulin will be primarily active after a carbohydrate-rich meal, helping to lower blood sugar by storing excess glucose as glycogen.

55
Q

If a person has not eaten for several hours and their blood glucose is low, which hormone becomes more active, and what does it do?

A

Glucagon becomes more active when blood glucose is low, breaking down glycogen into glucose for brain cells while other cells use ketones for energy.

56
Q

What is the energy homeostasis system?

A

The energy homeostasis system is the body’s mechanism for balancing energy by monitoring and responding to energy needs, primarily through processes in the liver and brain.

57
Q

How does the liver contribute to energy homeostasis?

A

Cells in the liver monitor blood glucose levels and send this information to the brain via the vagus nerve, which helps regulate hunger.

58
Q

What role does blood glucose play in controlling hunger?

A

Blood glucose levels influence hunger, with lower levels increasing hunger, although other factors like stomach signals also affect hunger.

59
Q

How does the stomach communicate hunger to the brain?

A

When the stomach is empty, it releases the hormone ghrelin, which travels to the brain and increases hunger.

60
Q

What is ghrelin, and what effect does it have on hunger?

A

Ghrelin is a hormone released by the empty stomach, increasing hunger levels when it reaches the brain.

61
Q

How do stretching of the stomach and hormone release affect hunger when eating?

A

The stomach and intestines send satiety signals through stretching and by releasing hormones that communicate fullness to the brain.

62
Q

What role do CCK and GLP-1 play in digestion and satiety?

A

CCK and GLP-1 are hormones released by the intestines during digestion that promote satiety and trigger the release of digestive enzymes and insulin.

63
Q

Why doesn’t regular CCK administration lead to sustained weight loss?

A

Although CCK reduces meal size, it tends to increase meal frequency, so it doesn’t result in long-term weight loss.

64
Q

What are GLP-1 agonists, and how are they used in weight control?

A

GLP-1 agonists are drugs that mimic GLP-1, reducing hunger and supporting weight control by increasing feelings of fullness.

65
Q

How does the body monitor long-term fat storage?

A

The body tracks fat levels through the hormone leptin, which signals energy availability based on the size of fat stores.

66
Q

What is leptin, and how does it influence hunger?

A

Leptin is a hormone released by fat cells that signals energy sufficiency; low leptin levels trigger hunger, while high levels reduce hunger.

67
Q

How does leptin affect the hypothalamus in terms of satiety?

A

Leptin makes the hypothalamus more sensitive to short-term satiety signals like CCK and GLP-1, enhancing fullness signals during meals.

68
Q

What happens when healthy individuals are given exogenous leptin?

A

Healthy individuals may experience a slight decrease in hunger temporarily, though the effect doesn’t last long.

69
Q

What is congenital leptin deficiency, and how does it affect the body?

A

Congenital leptin deficiency is a genetic condition where individuals cannot produce leptin, leading to extreme obesity and low metabolic rates.

70
Q

How does congenital leptin deficiency manifest in the Ob mouse strain?

A

The Ob mouse strain, which lacks leptin, exhibits extreme obesity and a low metabolic rate due to an inability to signal hunger and fullness accurately.

71
Q

Imagine someone feels hungry soon after eating a large meal. What might be a reason for this, considering the energy homeostasis system?

A

The person might have low leptin levels, making their hypothalamus less sensitive to fullness signals, leading them to feel hungry despite eating.

72
Q

What is glucoprivation?

A

Glucoprivation is a condition where blood sugar levels drop too low (hypoglycemia), causing intense hunger. This can happen due to factors like excessive insulin or certain drugs that lower glucose in the blood.

73
Q

What is lipoprivation?

A

Lipoprivation occurs when fat levels or free fatty acids in the blood are very low, triggering hunger. This condition can result from drugs that prevent fat from being used properly in the body.

74
Q

Why does the body activate emergency hunger circuits?

A

The body activates emergency hunger circuits when blood glucose or fat levels drop to critical lows. These circuits override normal hunger and fullness signals to prioritize eating and replenish energy.

75
Q

How does the body respond when emergency hunger circuits are activated?

A

When emergency hunger circuits are activated, the body decreases insulin, increases glucagon, ignores fullness signals, slows down energy use, and creates an intense feeling of hunger.

76
Q

What is diabetes, and how does it affect insulin?

A

Diabetes is a condition where the body either does not respond well to insulin or does not produce enough of it, leading to high blood sugar levels and difficulty converting sugar into fat for storage.

77
Q

Why might someone with diabetes feel hungry even when their blood sugar is high?

A

In diabetes, low leptin levels due to decreasing fat stores can trigger a hunger response, even if there is plenty of sugar in the blood.

78
Q

What are AGRP/NPY neurons, and what role do they play in hunger?

A

AGRP/NPY neurons in the arcuate nucleus of the hypothalamus promote feelings of hunger. They are activated by ghrelin (hunger hormone) and inhibited by leptin (fullness hormone).

79
Q

What are POMC neurons, and how do they affect hunger?

A

POMC neurons help reduce hunger. They are activated by leptin (which signals fullness) and inhibited by ghrelin (which signals hunger).

80
Q

How does the balance between AGRP/NPY and POMC neurons influence hunger?

A

The balance of activity between AGRP/NPY neurons (promote hunger) and POMC neurons (reduce hunger) helps regulate how hungry a person feels.

81
Q

What is the function of the Paraventricular Nucleus (PVN) in hunger regulation?

A

The PVN is a group of neurons in the hypothalamus involved in hunger. When certain neurons in the PVN are inhibited, it can lead to strong feelings of hunger, especially during lipoprivation (low fat levels).

82
Q

If a person takes a drug that blocks the use of fat in the body, which emergency hunger circuit would likely be activated?

A

Lipoprivation would be activated, as low fat levels or free fatty acids would trigger hunger to prompt eating and replenish energy stores.

83
Q

Imagine a patient with diabetes who often feels hungry despite high blood sugar levels. What could be causing this?

A

This patient might be experiencing low leptin levels due to reduced fat stores, which triggers hunger even when blood sugar is high.

84
Q

Why might the body ignore fullness signals during an energy shortage?

A

During an energy shortage, the body’s priority is to restore energy. Ignoring fullness signals ensures continued eating to quickly replenish glucose and fat stores.

85
Q

If AGRP/NPY neurons are constantly active, what sensation would this person experience?

A

The person would likely feel a persistent sense of hunger, as AGRP/NPY neurons are responsible for promoting hunger.

86
Q

What is Prader-Willi Syndrome?

A

Prader-Willi Syndrome is a genetic disorder caused by the absence of up to seven genes on chromosome 15, which affects growth and the survival of PVN neurons.

87
Q

What are the early life characteristics of individuals with Prader-Willi Syndrome?

A

Individuals with Prader-Willi Syndrome are born with very little muscle mass and initially show little interest in eating.

88
Q

How does hunger develop in individuals with Prader-Willi Syndrome?

A

Between the ages of 2 and 8, individuals develop an intense and constant feeling of hunger that can be extremely uncomfortable, making them feel as if they are starving.

89
Q

What is the average lifespan of individuals with Prader-Willi Syndrome in the United States?

A

The average lifespan of individuals with Prader-Willi Syndrome in the United States is around 30 years, with many dying from obesity-related complications.

90
Q

What is a significant health risk for individuals with Prader-Willi Syndrome?

A

A significant health risk is the lack of satiety signals, which can lead to overeating to the point of causing stomach rupture, a life-threatening condition.

91
Q

How does Prader-Willi Syndrome relate to the modern obesity epidemic?

A

The syndrome exemplifies how genetic factors can influence obesity, as genetic predisposition and environmental factors together contribute to body weight issues.

92
Q

What is hedonic hunger?

A

Hedonic hunger refers to the pleasure aspect of eating, where individuals find food enjoyable even when they are not physically hungry.

93
Q

How do genetic differences affect metabolism in relation to obesity?

A

Genetic differences influence how efficiently individuals convert food into energy, contributing to variations in body fat among people.

94
Q

What is the mismatch between genetics and food environment in the context of obesity?

A

The mismatch occurs because our lifestyles and food availability are changing faster than our genetics can adapt, leading to issues for those with genetic predispositions that do not align with modern food environments.

95
Q

What is bariatric surgery?

A

Bariatric surgery is a surgical intervention designed to reduce the amount of food a person can eat during a meal, aiding in weight management.

96
Q

What is Roux-en-Y gastric bypass (RYGB)?

A

Roux-en-Y gastric bypass is a type of bariatric surgery that alters the stomach and small intestine by connecting a smaller stomach directly to the jejunum, significantly reducing food capacity.

97
Q

What impact does Roux-en-Y gastric bypass have on hunger levels?

A

Many individuals experience reduced hunger after the surgery over time, though researchers do not fully understand the underlying mechanisms behind this change.

98
Q

How are hormones like GLP-1 relevant to understanding obesity?

A

Hormones released by the gut, such as GLP-1, are being studied to better understand how they influence hunger and the constant thoughts some individuals have about food.