Lecture 12 - Touch, Taste, Smell Flashcards

1
Q

What is the somatosensory system?

A

The somatosensory system provides information about touch, pressure, temperature, and pain from both the skin’s surface and inside the body.

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2
Q

What are the three interacting systems within the somatosensory system?

A

The three interacting systems are the exteroceptive system (skin senses), the interoceptive system (organic senses), and the proprioceptive system (kinesthesia).

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3
Q

What does the exteroceptive system respond to?

A

The exteroceptive system responds to outside stimuli that touch the skin, such as touch and temperature.

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4
Q

What is the role of the interoceptive system?

A

The interoceptive system provides information about internal conditions of the body and helps regulate processes like heart rate, breathing, hunger, and bladder control.

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5
Q

What is kinesthesia, and which system does it belong to?

A

Kinesthesia, part of the proprioceptive system, is the sense of body position, posture, and movement, including muscle tension.

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6
Q

What types of stimuli do the cutaneous senses encode?

A

The cutaneous senses encode pressure (touch), vibrations, temperature, and pain.

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7
Q

Which skin layer provides oxygen to cells directly from the air?

A

The epidermis, the outermost layer of skin, provides oxygen directly from the air to its cells.

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8
Q

What is the role of Merkel’s disks?

A

Merkel’s discs are specialized mechanoreceptors that detect light touch and pressure, located in the skin’s epidermis, particularly in areas like the fingertips and hairless skin. They detect simple touch, like gentle contact with the skin.

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9
Q

Which sensory receptor helps sense skin stretching and finger position?

A

Ruffini corpuscles sense skin stretching and help with finger position and movement.

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10
Q

Where are Meissner’s corpuscles found, and what do they detect?

A

Meissner’s corpuscles are found in glabrous (hairless) skin and are involved in detecting dynamic, light touch (e.g., feeling Braille)

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11
Q

How do temperature receptors function in the skin?

A

Temperature receptors detect warmth or coolness, and some also send pain signals. The axons of these receptors have little or no myelin (the protective coating around nerve fibers), which makes their signals slower and less precise compared to other sensory neurons with more myelin.

(Temperature receptors don’t need to be fast, since they are often detecting less urgent sensations like mild changes in temperature or discomfort, rather than immediate, sharp pain or touch.)

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12
Q

Which chemicals activate temperature receptors, and how?

A

Capsaicin (in chili peppers) activates heat receptors, while menthol (in mint) activates cold receptors.

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13
Q

What are nociceptors?

A

Nociceptors are pain receptors that detect harmful stimuli, including strong pressure and extreme temperatures.

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14
Q

What type of pain do high-threshold mechanoreceptors detect?

A

High-threshold mechanoreceptors respond to strong pressure, such as hitting, stretching, or pinching.

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15
Q

How do signals from the body reach the primary somatosensory cortex?

A

Sensory signals from the body travel through spinal nerves into the central nervous system (CNS). These signals take one of two pathways: the spinothalamic tract (which transmits pain and temperature) or the dorsal column (which carries touch and proprioception information). These pathways converge in the midbrain, where they are processed further, and then continue to the thalamus. The thalamus acts as a relay station, directing the signals to the primary somatosensory cortex in the parietal lobe, where they are interpreted as sensations like touch, pain, and temperature.

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16
Q

What is the spinothalamic tract, and what type of sensations does it carry?

A

The spinothalamic tract carries less precise sensations, like general touch, temperature, and pain, crossing to the opposite side of the spinal cord early on.

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17
Q

Which pathway carries fine touch information to the brain, and where does it cross sides?

A

The dorsal column pathway carries fine touch information and crosses sides in the medulla before continuing to the thalamus.

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18
Q

Imagine you touch a hot stove with your hand. Which receptors and pathways are involved in detecting and processing this sensation?

A

Temperature and pain are detected by free nerve endings, with signals sent via the spinothalamic tract to the thalamus and then to the primary somatosensory cortex.

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19
Q

If someone feels a light touch on their palm, which receptors are likely involved?

A

Meissner’s corpuscles, which detect light touch and are located in glabrous (hairless) skin like the palm, are likely involved.

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20
Q

What is the somatosensory homunculus?

A

The somatosensory homunculus is a map of the body surface, representing how different areas of the primary somatosensory cortex correspond to sensations in specific body parts.

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21
Q

How does the somatosensory homunculus demonstrate the connection between the brain and body sensations?

A

By stimulating different areas of the primary somatosensory cortex, sensations are felt in specific body parts, which reveals the brain’s organization of sensory input from the body.

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22
Q

Why might stimulating the primary somatosensory cortex create a sensation in a particular body part?

A

Each region of the somatosensory cortex is mapped to a specific body part, so electrical stimulation of these regions can produce a sensation as if that body part were being touched.

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23
Q

What is tactile agnosia?

A

Tactile agnosia is a condition where patients have difficulty recognizing objects by touch alone, often mistaking one object for another.

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24
Q

How might tactile agnosia affect a patient’s daily life?

A

A person with tactile agnosia might struggle to identify objects by feel, which could make tasks like finding items in a bag difficult. However, they might recognize these objects if they can see or draw them.

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25
Q

Imagine a person with tactile agnosia picks up a pine cone. What might they experience?

A

They might describe the pine cone as feeling like a different object, such as a brush, due to their inability to recognize it by touch alone.

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26
Q

What is phantom limb pain?

A

Phantom limb pain is a sensation where individuals feel as if their amputated limb is still present and may even experience pain in that missing limb.

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27
Q

Why might a person with an amputated limb still feel pain in the area where their limb used to be?

A

Phantom limb pain may be caused by the brain receiving mixed signals from nerves that were once connected to the limb, confusing the brain about the limb’s presence.

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28
Q

What is the mirror box treatment, and what is it used for?

A

The mirror box treatment is a method for alleviating phantom limb pain by creating an illusion of the missing limb using a mirror to “trick” the brain into perceiving movement in the limb.

29
Q

What are the six types of taste receptors?

A

The six types of taste receptors are sweetness, umami, bitterness, saltiness, sourness, and fat.

30
Q

Which taste receptor detects sugar molecules?

A

The sweetness receptor detects sugar molecules.

31
Q

What does the umami receptor detect, and where is this flavor commonly found?

A

The umami receptor detects glutamate/glutamine, commonly found in meat and cheese. It can also be activated by MSG.

32
Q

How do bitterness receptors differ from other taste receptors?

A

Bitterness receptors are unique because they detect a wide variety of bitter molecules using approximately 50 different receptor types.

33
Q

Which ions are detected by the saltiness and sourness receptors?

A

The saltiness receptor detects sodium ions, while the sourness receptor detects free hydrogen ions, which indicate acidity.

34
Q

Describe a scenario where the taste receptor for fat might be activated.

A

When eating foods rich in fatty acids, such as oils or fatty meats, the receptors for fat are activated, allowing us to perceive the fatty taste.

35
Q

How does the perception of taste work similarly to synaptic transmission?

A

When a taste molecule binds to a taste receptor, it changes the receptor’s membrane potential, which then leads to the release of neurotransmitters, much like how synaptic transmission works in the brain.

36
Q

Why are taste receptor cells replaced frequently?

A

Taste receptor cells are replaced roughly every ten days because they are exposed to a harsh environment, which requires regular cell turnover.

37
Q

What role do G proteins play in taste perception?

A

In taste perception, G proteins are involved in signaling pathways that change the membrane potential of taste receptor cells, helping detect certain tastes like umami.

38
Q

What is taste transduction?

A

Taste transduction is the process by which taste molecules attach to taste receptor proteins, changing the cell membrane’s electrical charge, similar to how signals are transmitted at synapses.

39
Q

How do taste receptor proteins generate signals?

A

When a molecule binds to a taste receptor protein, it changes the cell membrane’s charge either directly through an ion channel or through G proteins.

40
Q

How do different tastes activate taste receptor cells?

A

Different tastes activate specific taste receptor proteins, each tuned to particular flavors like sweet, umami, bitter, salty, sour, or fatty.

41
Q

What makes taste receptor cells unique in terms of signal transmission?

A

Unlike typical neurons, taste receptor cells don’t produce traditional action potentials; instead, they release neurotransmitters in varying amounts.

42
Q

Why do taste receptor cells have a short lifespan?

A

Taste receptor cells are replaced approximately every ten days because they are exposed to a challenging environment in the mouth.

43
Q

What are odorants?

A

Odorants are tiny molecules that evaporate easily, often coming from living things, and are identified by the olfactory system.

44
Q

How do humans detect odorants?

A

Humans detect odorants using about 400 types of metabotropic G protein-coupled receptors, each sensitive to a specific molecule.

45
Q

Where are smell receptor cells located, and what structure do they connect to?

A

Smell receptor cells are located in the olfactory epithelium and connect to glomeruli in the olfactory bulb, which process specific odors.

46
Q

How can humans recognize up to 10,000 different smells with only 400 types of receptors?

A

Humans recognize many smells by using combinations of the 400 different receptor types, allowing for a broad range of scent detection.

47
Q

What makes the perception of smell unique compared to other senses?

A

Olfactory information bypasses the thalamus and goes directly to the primary olfactory cortex and the amygdala, unlike most other senses.

48
Q

How is our preference for different smells determined?

A

Unlike taste, preferences for smells are learned, not hardwired as “good” or “bad.”

49
Q

What are pheromones?

A

Pheromones are chemicals released by an animal to send signals to others of the same species, often triggering innate responses.

50
Q

In what ways do animals use pheromones?

A

Animals use pheromones to attract mates, create trails, and warn of danger, especially common in insects.

51
Q

How are pheromones detected in mammals?

A

Pheromones are detected by the vomeronasal organ and the accessory olfactory bulb, separate from the regular olfactory structures.

52
Q

What receptors are responsible for detecting pheromones?

A

Pheromones are detected by metabotropic vomeronasal receptors, which differ from regular olfactory receptors.

53
Q

Do humans have a vomeronasal organ?

A

Humans and other primates do not have a functioning vomeronasal organ; however, there may be some pheromone-like signaling in the regular olfactory system.

54
Q

Imagine a person loses the ability to taste salty foods. Which type of receptor might be malfunctioning?

A

The taste receptor protein responsible for detecting salty tastes may be malfunctioning, affecting their taste perception.

55
Q

If an animal releases chemicals that make others of the same species follow a trail, what is this an example of?

A

This is an example of pheromone signaling, as seen in behaviors like ants leaving trails.

56
Q

How are rodent pheromones detected?

A

Rodent pheromones are typically detected by sniffing or tasting, as they are usually present in urine rather than being airborne.

57
Q

What role does pheromone detection play in rodent sexual behavior?

A

Pheromone detection in rodents helps males identify females in heat and influences mate selection, affecting mating behavior and reproductive success.

58
Q

What behavior does a male mouse show if his vomeronasal system is functioning normally?

A

A male mouse with a functioning vomeronasal system will only try to mate with female mice that are in heat.

59
Q

What happens to a male mouse’s mating behavior if his vomeronasal system is damaged?

A

If a male mouse’s vomeronasal system is damaged, he may attempt to mate with any mouse, regardless of its gender or reproductive state.

60
Q

Describe the Lee-Boot Effect.

A

The Lee-Boot Effect occurs when female mice, kept together without exposure to male urine, experience a slowing or cessation of their estrous cycles.

61
Q

What is the Whitten Effect?

A

The Whitten Effect is when male mouse urine causes female mice to start their estrous cycles simultaneously.

62
Q

Explain the Vandenbergh Effect.

A

The Vandenbergh Effect is when female animals living with males start puberty earlier due to the presence of male pheromones.

63
Q

What is the Bruce Effect?

A

The Bruce Effect is when female rodents terminate their pregnancies if they detect the scent of an unfamiliar male.

64
Q

How does the urine of castrated male mice affect female rodents?

A

The urine of castrated male mice does not produce typical pheromone effects, such as the Whitten or Bruce Effects, in female rodents.

65
Q

Why are the effects of male pheromones on female rodents considered weak?

A

The effects of male pheromones on female rodents are weak because they are often subtle and challenging to reproduce reliably in studies.

66
Q

How do human studies compare to rodent studies regarding pheromone effects?

A

Human studies on pheromone effects, such as menstrual cycle synchronization among women living together, have shown mixed results and are difficult to replicate consistently.

67
Q

If a group of female mice is housed without any male urine, what effect is likely to be observed?

A

The Lee-Boot Effect may occur, where the estrous cycles of the female mice slow down or stop.

68
Q

Imagine a female rodent detects the scent of an unfamiliar male after mating. What behavioral or physiological response might she show?

A

She may exhibit the Bruce Effect, where she terminates her pregnancy in response to the scent of an unfamiliar male.

69
Q

In a colony of female mice, what effect might be observed if a castrated male mouse is introduced?

A

No significant pheromone effects (like estrous synchronization) would be observed because castrated male urine lacks the chemicals that produce these effects.