Lecture 15: Immunology - microbial pathogen recognition and eliminaton

Question 1

Where can microbials break through some anatomic barriers?

Answer 1

1. hair follicle pores

2. cuts

Question 2

How do pathogens defend them cells from phagocytosis?

Answer 2

1. Capsules
   a. some may be ‘slippery’ - phagocyte
   can’t get hold
   b. some may mimic cells of host
   c. others allow engulfing - but prevent
   fusion with lysosome

Question 3

What are the three types of inteferons?

Answer 3

1. Type 1:
   a. IFN-alpha & IFN-beta
   b. made by most cells
   c. high arrival frequency
2. Type 2:
   a. IFN-gamma
   b. immunomodulatory function: activating
   macrophages, NK-T-cells, and T cells to
   increase MHC-presented antigens
3. Type 3:
   a. IFN-lambda
   b. arrival responses
   c. epithelial cells