Lecture 14 Flashcards
1
Q
What is the role of folate?
A
The backbone of synthesis of purines and thymines.
2
Q
Deficiency in folate causes
A
Megaloblastic anaemia
3
Q
How many glutamate residues does medicinal foltate have?
A
1
4
Q
Folate supplementation prevents defects in what in pregnancy?
A
Neural tube development
5
Q
What removes glutamate residues in the lumen?
A
membrane-bound folate conjugase
6
Q
What is the apical transporter of folate?
A
PCFT (H+ coupled transporter)
7
Q
What does folate become inside the cell?
A
DHF and THF.
