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Gastro 1 > Lecture 11 > Flashcards

Lecture 11 Flashcards

1
Q

How many amino acid transporters are there at the BBM?

A

7

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2
Q

How many amino acid transporters are there at the BLM?

A

9

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3
Q

What system transports cationic amino acids at the BBM?

A

b0,+

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4
Q

What does the lower case b mean?

A

It is sodium independent transport.

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5
Q

What are two examples of amino acids transported?

A

Lysine and arginine

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6
Q

What other compound is moved by this system?

A

Cystine

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7
Q

What type of transport is this?

A

An electrogenic antiporter, it moved cationic amino acids in and effluxes neutral amino acids.

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8
Q

What are the two components of this transporter?

A

rBAT and BO+AT

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9
Q

Which one anchors the other?

A

rBAT anchors BO+AT to the membrane.

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10
Q

This system is defective in:

A

Cystinuria

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11
Q

How are the dibasic amino acids transported across the basolateral membrane?

A

By y+L. This is sodium dependent. It is electroneutral as the positive amino acid is exchanged for a sodium, and a neutral amino acid.

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12
Q

What are the two components of y+L?

A

CD98 and y+LAT1.

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13
Q

Lysinuric protein intolerance occurs because of a defect in what?

A

y+LAT1.

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14
Q

Why is lysinuric protein intolerance worse than cystinuria?

A

Because the dibasic amino acids are trapped inside the cell as they cant cross the BLM.

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15
Q

What system transports neutral amino acids across the apical membrane?

A

B0

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16
Q

What is B0

A

Electrogenic amino acid transporter than brings sodium in too. Also called BOAT1

17
Q

What disorder is BOAT1 defective in?

A

Hartnup disease.

18
Q

What is niacin?

A

The precurser for tryptophan

19
Q

Is sodium important for transport of alanine?

A

Yes, alanine is a neutral amino acid so it transported by the sodium dependent B0 system

20
Q

Glycine and proline are absorbed by

A

PAT1

21
Q

A general amino acid urea like Fanconi syndrome shows what in the urine?

A

Proline

22
Q

The R240Q residue of BOAT1 sits where?

A

on the outside of the protein distant from the catalytic site but used for linking with co-expressed proteins.

23
Q

What protein does BOAT1 attach to?

A

ACE2

Gastro 1 (14 decks)

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