lecture 14

Question 1

innat immunity

Answer 1

first line of defense rapid response to infection

Question 2

adaptive immunity

Answer 2

antigen specific and takes a longer time to fight against pathogen

Question 3

what are immune cells derived from

Answer 3

from hematopoietic stem cells

Question 4

HSC’S branch into which classification?

Answer 4

lymphoid and myeloid progenitors

Question 5

t cells derive from

Answer 5

hsc’s in bone marrow and mature in the thymus.

Question 6

apc

Answer 6

antigen presenting cell

Question 7

t cells have..

Answer 7

receptors that are activated by antigen presenting cells.

Question 8

MHC

Answer 8

major histocompatibility complex proteins that are on the surface of APCS

Question 9

class 1 mhc

Answer 9

intracellular peptides

Question 10

class 2 mhc

Answer 10

molecules which present extracellular peptides

Question 11

t/f the mhc protein displays fragments of antigens when a cells is infected with a pathogen

Answer 11

true

Question 12

true or false t cells are activated when they encounter apc that have antigens on its mhc molecules.

Answer 12

true

Question 13

cytotoxic t cells

Answer 13

involved in cell destruction

Question 14

memory cells

Answer 14

tcells and b cells

Question 15

clonal deletion

Answer 15

removal of b and t cells that have receptors of self that prevent recognition of self host cells

Question 16

clonal anergy theory

Answer 16

t or b cells become inactivated in the normal individual and cant amplify the immune response

Question 17

idiotype network theory

Answer 17

a network of antibodies neutralize self-reactive antibodies within the body

Question 18

triggers of autoimmune disrades

Answer 18

stress hormones foods

Question 19

phases of autoimmune disease

Answer 19

initiation propagation resulution

Question 20

initiation

Answer 20

genetic predisposition unaware of syptoms

Question 21

propagation

Answer 21

patients with disease have cytokine production, epitope spreadin and disrupted teff/treg balance

Question 22

resolution

Answer 22

cell extrinsic cell intrinsic autoimmune reactions resolve

Question 23

what is responsible for initiating autoimmune responses

Answer 23

genetic predisposition
environmental triggers
defective regulation

Question 24

t/f estrogen levels may play a role in women developing autoimmune diseases since 80 percent of cases occur in women

Answer 24

true

Question 25

artificial pancreas

Answer 25

machine which read insulin levels and pumps insulin

Question 26

arthritis occurs in a symmetrical pattern

Answer 26

true

Question 27

rheumatoid factor

Answer 27

antibody that is present in the blood of those with arthritis not always the case

Question 28

anti ccp antibodies

Answer 28

blood test that detects anti cyclic citrullinated antibodies. if positive then patient has arthritis

Question 29

treatment of RA

Answer 29

nsaids
anti rheumatic drugs (dmards)
steroids
biologics

Question 30

lupus

Answer 30

the body attack healthy cells and tissues anywhere in the body

Question 31

SLE

Answer 31

common type of lupus can impact many parts of body

Question 32

discoid lupus

Answer 32

causes red rash

Question 33

subacute cutaneous lupus

Answer 33

causes sores after being out in the sun

Question 34

drug induced lupus

Answer 34

cause by certain medicines

Question 35

neonatal lupus

Answer 35

impacts newborns

Question 36

hashimotos disease

Answer 36

hypothyroidism or underactive thyroid

Question 37

thyroid

Answer 37

part of the body which controls how the body uses energy