lecture 14 Flashcards
innat immunity
first line of defense rapid response to infection
adaptive immunity
antigen specific and takes a longer time to fight against pathogen
what are immune cells derived from
from hematopoietic stem cells
HSC’S branch into which classification?
lymphoid and myeloid progenitors
t cells derive from
hsc’s in bone marrow and mature in the thymus.
apc
antigen presenting cell
t cells have..
receptors that are activated by antigen presenting cells.
MHC
major histocompatibility complex proteins that are on the surface of APCS
class 1 mhc
intracellular peptides
class 2 mhc
molecules which present extracellular peptides
t/f the mhc protein displays fragments of antigens when a cells is infected with a pathogen
true
true or false t cells are activated when they encounter apc that have antigens on its mhc molecules.
true
cytotoxic t cells
involved in cell destruction
memory cells
tcells and b cells
clonal deletion
removal of b and t cells that have receptors of self that prevent recognition of self host cells
clonal anergy theory
t or b cells become inactivated in the normal individual and cant amplify the immune response
idiotype network theory
a network of antibodies neutralize self-reactive antibodies within the body
triggers of autoimmune disrades
stress hormones foods
phases of autoimmune disease
initiation propagation resulution
initiation
genetic predisposition unaware of syptoms
propagation
patients with disease have cytokine production, epitope spreadin and disrupted teff/treg balance
resolution
cell extrinsic cell intrinsic autoimmune reactions resolve
what is responsible for initiating autoimmune responses
genetic predisposition
environmental triggers
defective regulation
t/f estrogen levels may play a role in women developing autoimmune diseases since 80 percent of cases occur in women
true
artificial pancreas
machine which read insulin levels and pumps insulin
arthritis occurs in a symmetrical pattern
true
rheumatoid factor
antibody that is present in the blood of those with arthritis not always the case
anti ccp antibodies
blood test that detects anti cyclic citrullinated antibodies. if positive then patient has arthritis
treatment of RA
nsaids
anti rheumatic drugs (dmards)
steroids
biologics
lupus
the body attack healthy cells and tissues anywhere in the body
SLE
common type of lupus can impact many parts of body
discoid lupus
causes red rash
subacute cutaneous lupus
causes sores after being out in the sun
drug induced lupus
cause by certain medicines
neonatal lupus
impacts newborns
hashimotos disease
hypothyroidism or underactive thyroid
thyroid
part of the body which controls how the body uses energy
